The efficacy of a centrally active cholinesterase inhibitor, rivastigmine tartrate (ENA 713; Exelon®), in patients with mild to moderately severe Alzheimer’s disease was evaluated in a 26-week open-label extension of a 26-week, double-blind, placebo-controlled study. By 52 weeks, patients originally treated with 6–12 mg/day rivastigmine had significantly better cognitive function than patients originally treated with placebo.

Keywords:
Cholinesterase inhibitor, Rivastigmine, Clinical trial, Alzheimer’s disease
1.
Leber P: Observations and suggestions on antidementia drug development. Alzheimer Dis Assoc Disord 1996;10(suppl 1):31–35.
2.
Leber P: Slowing the progression of Alzheimer disease: Methodologic issues. Alzheimer Dis Assoc Disord 1997;11(suppl 5):10–21.
3.
Enz A, Amstutz R, Boddeke H, Gmelin G, Malanowski J: Brain selective inhibition of acetylcholinesterase: A novel approach to therapy for Alzheimer’s disease. Prog Brain Res 1993; 98:431–438.
4.
Cutler NR, Polinsky RJ, Sramek JJ, Enz A, Jhee SS, Mancione L, Hourani J, Zolnouni P: Dose-dependent CSF acetylcholinesterase inhibition by SDZ ENA 713 in Alzheimer’s disease. Acta Neurol Scand 1998;97:244–250.
5.
Corey-Bloom J, Anand R, Veach J: A randomized trial evaluating the efficacy and safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderately severe Alzheimer’s disease. Int J Geriatr Psychopharmacol 1998;1:55–65.
6.
Rösler M, Anand R, Cicin-Sain A, Gauthier S, Agid Y, Dal-Bianco P, Stähelin HB, Hartman R, Gharabawi M, on behalf of the B303 Exelon Study Group: Efficacy and safety of rivastigmine in patients with Alzheimer’s disease: International randomised controlled trial. Br Med J 1999;318:633–640.
7.
Rosen WG, Mohs RC, Davis KL: A new rating scale for Alzheimer’s disease. Am J Psychiatry 1984;141:1356–1364.
8.
Davis KL, Mohs RC, Marin D, Purohit DP, Perl DP, Lantz M, Austin G, Haroutunian V: Cholinergic markers in elderly patients with early signs of Alzheimer disease. JAMA 1999;15:1401–1406.
9.
Kramer-Ginsberg E, Mohs RC, Aryan M, Lobel D, Silverman J, Davidson M, Davis KL: Clinical predictors of course of Alzheimer patients in a longitudinal study: A preliminary report. Psychopharmacol Bull 1988;24:458–462.
10.
Stern RG, Mohs RC, Davidson M, Schmeidler J, Silverman J, Kramer-Ginsberg E, Searcey T, Bierer L, Davis KL: A longitudinal study of Alzheimer’s disease: Measurement, rate, and predictors of cognitive deterioration. Am J Psychiatry 1994;151:390–396.
© 2000 S. Karger AG, Basel
2000
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