IgE Reactivity Pattern to Timothy and Birch Pollen Allergens in Finnish and Russian KareliaMovérare R. · Petäys T. · Vartiainen E. · Haahtela T.
aPharmacia Diagnostics AB and Uppsala University, Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala, Sweden; bHelsinki University Central Hospital, Division of Allergy, and cDepartment of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
Background: Little is known about differences in IgE reactivity patterns to individual allergens in random populations. We studied the IgE reactivity profile to individual recombinant (r) and native (n) allergens in sera from subjects sensitized to timothy and/or birch pollen living in Finnish and Russian Karelia. Methods: Sera from IgE-sensitized adults were obtained from an epidemiological study on a random sample of 1,177 subjects. The IgE reactivity to pollen extracts and eight timothy (rPhl p 1, 2, 5, 6, 7, 11, 12 and nPhl p 4) and three birch pollen allergens (rBet v 1, 2 and 4) were analyzed with UniCAP®. Results: The levels of IgE antibodies to timothy and birch pollen were higher in Finnish (median 5.2, range 0.35 to >100 kUA/l,) than in Russian Karelia (median 1.8 kUA/l, range 0.43–25.2 kUA/l, p < 0.01). There was a significantly higher prevalence of IgE reactivity to three timothy pollen allergens in Finnish (n = 57) than in Russian Karelia (n = 12): rPhl p 2, 28 vs. 0%; rPhl p 5, 60 vs. 0%; rPhl p 6, 47 vs. 0%. The prevalence of IgE reactivity to the birch pollen allergens was similar in the two populations. IgE reactivity to rPhl p 2, 5, 6 and 11 was associated with hay fever symptoms. The timothy-pollen-specific serum IgE levels and the numbers of IgE reactivities to individual allergens correlated significantly (rs = 0.87, p < 0.0001). Conclusions: The data indicate that timothy- and birch pollen-specific IgE levels are higher in Finnish compared to Russian Karelia. This is reflected in wider IgE reactivity to individual timothy pollen allergens in Finnish Karelia, including the major allergen Phl p 5, and increased pollen allergy.
Correspondence to: Dr. Robert Movérare
Pharmacia Diagnostics AB, P.O. Box 6460
SE–751 37 Uppsala (Sweden)
Tel. +46 18 165060, Fax +46 18 166330
R. Movérare and T. Petäys contributed equally to the study, and both should be regarded as first authors.
Received: November 26, 2003
Accepted after revision: September 24, 2004
Published online: December 8, 2004
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 0, Number of References : 22
International Archives of Allergy and Immunology
Vol. 136, No. 1, Year 2005 (Cover Date: January 2005)
Journal Editor: Valenta, R. (Vienna)
ISSN: 1018–2438 (print), 1423–0097 (Online)
For additional information: http://www.karger.com/iaa