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Vol. 19, No. 2-3, 2005
Issue release date: February 2005
Section title: Original Research Article
Dement Geriatr Cogn Disord 2005;19:134–139
(DOI:10.1159/000082884)

Plasma Levels of Antioxidants Are Not Associated with Alzheimer’s Disease or Cognitive Decline

Engelhart M.J. · Ruitenberg A. · Meijer J. · Kiliaan A. · van Swieten J.C. · Hofman A. · Witteman J.C.M. · Breteler M.M.B.
Departments of aEpidemiology and Biostatistics and bNeurology, Erasmus Medical Center, Rotterdam, cNumico Research, Wageningen, dDepartment of Anatomy, University Medical Center, Nijmegen, The Netherlands

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 6/18/2004
Published online: 2/11/2005

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Antioxidants prevent oxidative stress that possibly causes neuronal loss in Alzheimer’s disease (AD). We examined whether high plasma levels of the antioxidant vitamins A and E were associated with lower prevalence of AD or cognitive decline (CD). We performed a cross-sectional study within the Rotterdam Study. In an univariate model, higher levels of vitamins A and E were significantly associated with lower prevalence of AD. However, when additional adjustments were made for important confounders, such as age, gender and total cholesterol, the relation substantially weakened – odds ratios per standard deviation increase were 0.87 (95% CI 0.64–1.19) for vitamin A and 0.94 (95% CI 0.60–1.48) for vitamin E. Antioxidants were not related to CD in non-demented subjects. Our findings suggest no association between plasma levels of vitamin A and E and AD or CD.


  

Author Contacts

Dr. M.M.B. Breteler
Department of Epidemiology & Biostatistics
Erasmus Medical Center, PO Box 1738 NL–3000 DR Rotterdam (The Netherlands)
Tel. +31 10 4087489, Fax +31 10 4089382, E-Mail m.breteler@erasmusmc.nl

  

Article Information

Accepted: June 18, 2004
Published online: December 23, 2004
Number of Print Pages : 6
Number of Figures : 2, Number of Tables : 3, Number of References : 26

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 19, No. 2-3, Year 2005 (Cover Date: Released February 2005)

Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/dem


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 6/18/2004
Published online: 2/11/2005

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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