Tau Protein, Aβ42 and S-100B Protein in Cerebrospinal Fluid of Patients with Dementia with Lewy BodiesMollenhauer B.a · Cepek L.a · Bibl M.b · Wiltfang J.d · Schulz-Schaeffer W.J.c · Ciesielczyk B.a · Neumann M.e · Steinacker P.b · Kretzschmar H.A.e · Poser S.a · Trenkwalder C.f · Otto M.a
Departments of aNeurology, bPsychiatry and cNeuropathology, Georg August University Göttingen, Göttingen, dDepartment of Psychiatry, Friedrich Alexander University Erlangen/Nuremberg, Erlangen, eDepartment of Neuropathology, Ludwig Maximilians University Munich, Munich, and fGeorg August University Göttingen, Paracelsus-Elena-Klinik, Kassel, Germany
The intra vitam diagnosis of dementia with Lewy bodies (DLB) is still based on clinical grounds. So far no technical investigations have been available to support this diagnosis. As for tau protein and β-amyloid(1–42) (Aβ42), promising results for the diagnosis of Alzheimer’s disease (AD) have been reported; we evaluated these markers and S-100B protein in cerebrospinal fluid (CSF), using a set of commercially available assays, of 71 patients with DLB, 67 patients with AD and 41 nondemented controls (NDC) for their differential diagnostic relevance. Patients with DLB showed significantly lower tau protein values compared to AD but with a high overlap of values. More prominent differences were observed in the comparison of DLB patients with all three clinical core features and AD patients. Aβ42 levels were decreased in the DLB and AD groups versus NDC, without significant subgroup differences. S-100B levels were not significantly different between the groups. Tau protein levels in CSF may contribute to the clinical distinction between DLB and AD, but the value of the markers is still limited especially due to mixed pathology. We conclude that more specific markers have to be established for the differentiation of these diseases.
Dr. Brit Mollenhauer
Neurologische Klinik und Poliklinik, Georg-August-Universität Göttingen
Robert-Koch-Strasse 40, DE–37075 Göttingen (Germany)
Tel. +49 551 39 8404, Fax +49 551 39 14449
The study was supported in part by a grant from the Bundesministerium für Gesundheit, Berlin, Germany, to Drs. M.O. and S.P.
Accepted: June 18, 2004
Published online: January 5, 2005
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 2, Number of References : 34
Dementia and Geriatric Cognitive Disorders
Vol. 19, No. 2-3, Year 2005 (Cover Date: Released February 2005)
Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/dem