Cardiovascular disease has increased substantially in countries of central and eastern Europe and remains the major cause of premature death in Western populations. Cholesterol plays the major role in the underlying cause of cardiovascular disease, namely atherosclerosis. Epidemiological studies have demonstrated the prospective, strong and dose-dependent relationship between low density lipoprotein cholesterol and cardiovascular disease. In addition, evidence from molecular biology and randomized clinical trials supports the concept that elevated low density lipoprotein cholesterol is both sufficient and necessary for the development of atherosclerosis. Other risk factors than cholesterol greatly enhance the likelihood of symptomatic disease. Monogenic lipid disorders including familial hypercholesterolemia and familial defective apolipoprotein B illustrate the consequences of the dysregulation of cholesterol metabolism.
© 2005 S. Karger AG, Basel
Serena Tonstad, MD, PhD
Department of Preventive Cardiology, Preventive Medicine Clinic
Ullevål University Hospital
NO–0047 Oslo (Norway)
Tel. +47 22 11 79 39, Fax +47 22 11 99 75, E-Mail firstname.lastname@example.org
Published online: January 19, 2005
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 0, Number of References : 41
Heart Drug (Excellence in Cardiovascular Trials)
Vol. 5, No. 1, Year 2005 (Cover Date: January-March 2005)
Journal Editor: Atar, D. (Oslo)
ISSN: 1422–9528 (print), 1424–0556 (Online)
For additional information: http://www.karger.com/hed
Article / Publication Details
Published online: 2/7/2005
Issue release date: January–March 2005
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 1422-9528 (Print)
eISSN: 1424-0556 (Online)
For additional information: http://www.karger.com/HED
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