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Table of Contents
Vol. 72, No. 1, 2005
Issue release date: January – February
Section title: Thematic Review Series 2005
Respiration 2005;72:9–25
(DOI:10.1159/000083394)

Strategic Targets of Essential Host-Pathogen Interactions

Blasi F. · Tarsia P. · Aliberti S.
Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore Milano, Milano, Italy

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Article / Publication Details

First-Page Preview
Abstract of Thematic Review Series 2005

Published online: February 28, 2005
Issue release date: January – February

Number of Print Pages: 17
Number of Figures: 2
Number of Tables: 2

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

This review summarizes the present concepts regarding the biological processes that mediate intrinsic and innate host defense against microbial invasion of the lung. Innate immunity is the first line of defense of the higher organisms towards invading pathogens. It accomplishes a wide variety of activities including recognition and effector functions. The innate responses use phagocytic cells (macrophages, monocytes, and neutrophils), cells that release inflammatory mediators (basophils, mast cells, and eosinophils), and natural killer cells. The molecular component of innate responses includes complement, acute-phase proteins, and cytokines. Recognition of pathogen-associated molecular patterns is mediated by the pathogen receptors of the innate immune system, among these molecules toll-like receptors have emerged as fundamental components in the innate immune responses to infection, and a link between innate and adaptive immunity. Additional protection comes from polypeptide mediators of the innate host defense, such as the defensins and other antibiotic peptides. In view of the considerable burden in terms of mortality and morbidity that severe infections still pose worldwide, a better understanding of the biological basis of host-pathogen interactions opens stimulating future treatment perspectives.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Thematic Review Series 2005

Published online: February 28, 2005
Issue release date: January – February

Number of Print Pages: 17
Number of Figures: 2
Number of Tables: 2

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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