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Table of Contents
Vol. 42, No. 2, 2005
Issue release date: March – April
Section title: Short Communication
J Vasc Res 2005;42:133–136
(DOI:10.1159/000083502)

Decreased Whole Body Endogenous Nitric Oxide Production in Patients with Primary Pulmonary Hypertension

Demoncheaux E.A.G.a · Higenbottam T.W.c · Kiely D.G.b · Wong J.-M.a · Wharton S.a · Varcoe R.a · Siddons T.a · Spivey A.C.d · Hall K.e · Gize A.P.e
aDivision of Clinical Sciences (South), University of Sheffield, Royal Hallamshire Hospital, and bRespiratory Function Unit, Sheffield Teaching Hospital NHS Trust, Sheffield, cAstraZeneca R&D Charnwood, Loughborough, dDepartment of Chemistry, South Kensington Campus, Imperial College, London, and eManchester Medical Mass Spectrometry Facility, Unit A Millbrook Business Centre, Manchester, UK

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: August 05, 2004
Accepted: November 22, 2004
Published online: April 13, 2005
Issue release date: March – April

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR

Abstract

Impaired pulmonary release of nitric oxide (NO) is one of the characteristic phenotypic changes of vascular cells in pulmonary hypertension. The aim of this study was to determine nitric oxide synthase (NOS)-dependent whole body NO production in patients with primary pulmonary hypertension. NOS-dependent whole body NO production was assessed by giving an intravenous infusion of L-[15N]2-arginine (50 µmol/min for 30 min) and measuring isotopic urinary enrichment of 15N-nitrite and 15N-nitrate. Four female patients with no signs of infection were recruited and compared with 6 age-matched control subjects. Mean 12-hour excretion of 15N-nitrite and 15N-nitrate in the total urine over 36 h was smaller in patients than in control subjects (57.2 ± 27.6 vs. 229.1 ± 65.2 nmol/mmol creatinine, p< 0.01, Mann-Whitney U test, respectively). Neither mean 12-hour excretion of 14N-nitrite and 14N-nitrate (51.6 ± 10.0 vs. 72.4 ± 10.0 µmol/mmol creatinine, p = 0.3) nor glomerular filtration rates (84.5 ± 15.8 vs. 129.7 ± 16.0 ml/min, p = 0.1) were different between patients and control subjects. Our results suggest that either basal NOS-dependent whole body NO production is impaired or excess NO metabolism occurs in patients with primary pulmonary hypertension.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: August 05, 2004
Accepted: November 22, 2004
Published online: April 13, 2005
Issue release date: March – April

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 1018-1172 (Print)
eISSN: 1423-0135 (Online)

For additional information: http://www.karger.com/JVR


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