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Table of Contents
Vol. 27, No. 1, 2005
Issue release date: January – February
Section title: Original Paper
Dev Neurosci 2005;27:20–26
(DOI:10.1159/000084529)

Co-Transplantation of Schwann Cells Promotes the Survival and Differentiation of Neural Stem Cells Transplanted into the Injured Spinal Cord

Zeng Y.-S.a · Ding Y.a · Wu L.-Z.a · Guo J.-S.a · Li H.-B.a · Wong W.-M.b · Wu W.-T.b
aDivision of Neuroscience, Department of Histology and Embryology, Zhongshan Medical College, Sun Yat-Sen University at Guangzhou, Guangzhou, and bDepartment of Anatomy, Faculty of Medicine, University of Hong Kong, Hong Kong, China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 01, 2004
Accepted: October 19, 2004
Published online: May 11, 2005
Issue release date: January – February

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 3

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

Abstract

The present study investigates whether Schwann cells (SCs) could promote the survival and differentiation of neural stem cells in the injured spinal cord. Neural stem cells were dissociated and cloned from the hippocampal tissue of newborn rats. SCs were also dissociated and purified simultaneously from the sciatic nerves of 4-day-old rats. The results showed that the number of surviving neural stem cells and differentiated neuron-like cells was significantly increased in the co-grafted (SCs and neural stem cells) group compared with the control group (neural stem cells only). Neuron-like cells that developed axon-like processes were observed more commonly in the co-grafted group. These results demonstrate that SCs can promote the survival and differentiation of transplanted neural stem cells in the injured spinal cord.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 01, 2004
Accepted: October 19, 2004
Published online: May 11, 2005
Issue release date: January – February

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 3

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE


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