Cerebral Blood Flow in Parkinson’s Disease, Dementia with Lewy Bodies, and Alzheimer’s Disease according to Three-Dimensional Stereotactic Surface Projection ImagingKasama S. · Tachibana H. · Kawabata K. · Yoshikawa H.
Division of Neurology and Stroke Care Unit, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
Regional brain perfusion was analyzed using single-photon emission computed tomography with three-dimensional stereotactic surface projections (3D-SSP) in 69 patients with Parkinson’s disease (PD), 16 patients with dementia with Lewy bodies (DLB) and 15 patients with Alzheimer’s disease (AD), and compared with that in 24 age-equivalent normal subjects. Nondemented PD patients revealed less parietal and frontal flow than controls. With mental impairment, flow reduction extended to other areas including occipital regions. PD with dementia and DLB showed similar reduction patterns, although frontal flow showed a greater reduction in DLB. AD showed little occipital reduction, but a severe parieto-temporal reduction. Thus, 3D-SSP appears to be useful in the detection of cortical lesions and the differential diagnosis of patients with cognitive impairment.
© 2005 S. Karger AG, Basel
Hisao Tachibana, MD, PhD
Division of Neurology and Stroke Care Unit
Department of Internal Medicine, Hyogo College of Medicine
1-1, Mukogawa-cho, Nishinomiya 663-8501 (Japan)
Tel. +81 798 45 6596, Fax +81 798 45 6597, E-Mail firstname.lastname@example.org
Accepted: September 30, 2004
Published online: March 18, 2005
Number of Print Pages : 10
Number of Figures : 5, Number of Tables : 1, Number of References : 56
Dementia and Geriatric Cognitive Disorders
Vol. 19, No. 5-6, Year 2005 (Cover Date: May-June 2005)
Journal Editor: V. Chan-Palay, New York, N.Y.
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/dem