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Original Paper

What Has Diffusion Imaging in Animals Told Us about Diffusion Imaging in Patients with Ischaemic Stroke?

Rivers C.S. · Wardlaw J.M.

Author affiliations

Division of Clinical Neurosciences, Western General Hospital, Edinburgh, UK

Related Articles for ""

Cerebrovasc Dis 2005;19:328–336

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 08, 2004
Accepted: January 02, 2005
Published online: April 28, 2005
Issue release date: April 2005

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 4

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background and Purpose: In acute ischaemic stroke, the amount (and type) of cellular damage underlying diffusion-weighted imaging (DWI) lesion appearances is unclear.We summarized all information from experimental studies of DWI in focal ischaemia models. Methods: We systematically reviewed all published studies of DWI in focal ischaemic stroke models. We extracted key experimental details to determine correlations between histological features and DWI lesion characteristics. Results: Of 141 potentially eligible papers (including more than 2,817 animals, mostly rats), details of key experimental methods were unfortunately often omitted. Consistent findings amongst high-quality studies with blinded analysis included: neuronal damage persists or progresses despite early DWI lesion ‘normalisation’; the apparent diffusion coefficient is not very sensitive to the amount of neuronal damage; the ‘brighter’ the DWI lesion, the greater the neuronal damage; and the DWI lesion may reflect glial more than neuronal changes. Anaesthesia and fixation techniques may inadvertently affect these findings. Conclusions: The relationship between cellular damage and DWI lesion appearance, particularly recovery patterns in reperfusion experiments, remains imprecise. Key experimental details could be reported more completely and consistently. Potential problems from repeated anaesthetics need to be addressed. Early DWI lesion ‘recovery’ in acute stroke patients may largely reflect glial rather than neuronal ‘recovery’.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 08, 2004
Accepted: January 02, 2005
Published online: April 28, 2005
Issue release date: April 2005

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 4

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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