Neural Correlates of Impaired Performance on the Clock Drawing Test in Alzheimer’s DiseaseNagahama Y. · Okina T. · Suzuki N. · Nabatame H. · Matsuda M.
aDepartment of Geriatric Neurology, and bNeurology, Shiga Medical Center, Moriyama, Moriyama City, Shiga, Japan
To identify the neural correlates for impaired performance on the clock drawing test (CDT) in patients with Alzheimer’s disease (AD), we examined the relationship between the CDT performances and the regional cerebral blood flow (rCBF) in 100 AD patients. The patients were equally divided into a mildly impaired CDT group, a severely impaired CDT group, and two normal CDT groups, with age and dementia severity matched. Between-group comparisons revealed that rCBF reduction in the posterolateral region of the left temporal lobe was consistently associated with mild to severe impairment of the CDT in AD. Correlation analysis also showed that the rCBF in the left posterolateral temporal cortex was linearly correlated with CDT performance. The CDT scores in AD were significantly improved for the copy condition relative to the drawing-to-command condition. These findings suggest that CDT performance has a close relationship with the left posterior temporal function, and that semantic memory deficit may at least partly contribute to impaired CDT performance in AD.
Department of Geriatric Neurology, Shiga Medical Center
5-4-30 Moriyama, Moriyama-city, Shiga 524-8524 (Japan)
Tel. +81 77 582 5031, Fax +81 77 582 5426
Accepted: November 1, 2004
Published online: March 30, 2005
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 2, Number of References : 21
Dementia and Geriatric Cognitive Disorders
Vol. 19, No. 5-6, Year 2005 (Cover Date: May-June 2005)
Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)
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