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Vol. 49, No. 2, 2005
Issue release date: March–April 2005
Section title: Original Paper
Ann Nutr Metab 2005;49:77–82
(DOI:10.1159/000084739)

Effects of Intermittent Fasting on Serum Lipid Levels, Coagulation Status and Plasma Homocysteine Levels

Benli Aksungar F. · Eren A. · Ure S. · Teskin O. · Ates G.
Departments of aBiochemistry, bMicrobiology, cMetabolism and Nutrition, dCardiovascular Surgery and eCardiology, School of Medicine, Maltepe University, Istanbul, Turkey

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/8/2004
Accepted: 12/27/2004
Published online: 5/24/2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Background: During Ramadan, Muslims fast during the daylight hours for a month. The duration of restricted food and beverage intake is approximately 12 h/day which makes Ramadan a unique model of intermittent fasting. Many physiological and psychological changes are observed during Ramadan that are probably due to the changes in eating and sleeping patterns. Methods: Serum total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), prothrombin time, activated partial thromboplastin time (aPTT), plasma fibrinogen, D-dimer and homocysteine levels were measured in 24 healthy fasting volunteers (12 females, 12 males) aged 21–35 years. Venous blood samples were taken 1 week before Ramadan, on the 21st day of Ramadan and 20 days after Ramadan. Results: No significant changes were observed on serum total cholesterol, triglycerides and LDL levels. HDL levels were significantly elevated during Ramadan (p < 0.001) and 20 days after Ramadan (p < 0.05). Prothrombin time, aPTT, fibrinogen and D-dimer levels were in the physiologic limits in all samples but D-dimer levels were significantly low at the end of Ramadan in comparison to pre- and post-fasting levels (p < 0.001). Homocysteine levels, being still in reference ranges, were low during Ramadan (p < 0.05) and reached the pre-fasting levels after Ramadan. Conclusion: Our results demonstrate that intermittent fasting led to some beneficial changes in serum HDL and plasma homocysteine levels, and the coagulation status. These changes may be due to omitting at least one meal when the body was particularly metabolically active and possibly had a low blood viscosity level at the same time. We conclude that intermittent fasting may have beneficial effects on hemostatic risk markers for cardiovascular diseases.


  

Author Contacts

Dr. Fehime Benli Aksungar
Department of Biochemistry
School of Medicine, Maltepe University
Atatürk Caddesi, çam Sok, No 3/A, Maltepe/İstanbul (Turkey)
Tel. +90 216 3999750/4591724, Fax +90 216 3709719, E-Mail fehimebenli@hotmail.com

  

Article Information

Received: October 8, 2004
Accepted: December 27, 2004
Published online: March 29, 2005
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 2, Number of References : 30

  

Publication Details

Annals of Nutrition and Metabolism (European Journal of Nutrition, Metabolic Diseases and Dietetics)

Vol. 49, No. 2, Year 2005 (Cover Date: March-April 2005)

Journal Editor: Elmadfa, I. (Vienna)
ISSN: 0250–6807 (print), 1421–9697 (Online)

For additional information: http://www.karger.com/anm


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 10/8/2004
Accepted: 12/27/2004
Published online: 5/24/2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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