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Vol. 110, No. 1-4, 2005
Issue release date: 2005
Section title: Retrotransposable Elements, Retrotransposition and Genome Evolution
Cytogenet Genome Res 110:35–48 (2005)
(DOI:10.1159/000084936)

LINEs, SINEs and processed pseudogenes: parasitic strategies for genome modeling

Dewannieux M. · Heidmann T.
Unité des Rétrovirus Endogènes et Eléments Rétroïdes des Eucaryotes Supérieurs, UMR 8122 CNRS, Institut Gustave Roussy, Villejuif (France)

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Article / Publication Details

First-Page Preview
Abstract of Retrotransposable Elements, Retrotransposition and Genome Evolution

Published online: 7/21/2005
Issue release date: 2005

Number of Print Pages: 14
Number of Figures: 5
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Two major classes of retrotransposons have invaded eukaryotic genomes: the LTR retrotransposons closely resembling the proviral integrated form of infectious retroviruses, and the non-LTR retrotransposons including the widespread, autonomous LINE elements. Here, we review the modeling effects of the latter class of elements, which are the most active in humans, and whose enzymatic machinery is subverted to generate a large series of “secondary” retroelements. These include the processed pseudogenes, naturally present in all eukaryotic genomes possessing non-LTR retroelements, and the very successful SINE elements such as the human Alu sequences which have evolved refined parasitic strategies to efficiently bypass the original “protectionist” cis-preference of LINEs for their own retrotransposition.   

© 2005 S. Karger AG, Basel


  

Author Contacts

Request reprints from Thierry Heidmann, Unité des Rétrovirus Endogènes et
Eléments Rétroïdes des Eucaryotes Supérieurs, UMR 8122 CNRS
Institut Gustave Roussy, 39 rue Camille Desmoulins
FR–94805 Villejuif Cedex (France); telephone: 33 1-42-11-49-70
fax: 33 1-42-11-53-42; e-mail: heidmann@igr.fr

  

Article Information

Supported by the CNRS and the Ligue Nationale Contre le Cancer.

Manuscript received 6 March 2004;
accepted in revised form for publication by J.-N. Volff 22 April 2004.
Number of Print Pages : 14
Number of Figures : 5, Number of Tables : 0, Number of References : 147

  

Publication Details

Cytogenetic and Genome Research

Vol. 110, No. 1-4, Year 2005 (Cover Date: 2005)

Journal Editor: H.P. Klinger, Bronx, N.Y.; M. Schmid, Würzburg
ISSN: 1424–8581 (print), 1424–859X (Online)

For additional information: http://www.karger.com/cgr


Article / Publication Details

First-Page Preview
Abstract of Retrotransposable Elements, Retrotransposition and Genome Evolution

Published online: 7/21/2005
Issue release date: 2005

Number of Print Pages: 14
Number of Figures: 5
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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