How mobile genetic elements molded eukaryotic genomes is a key evolutionary question that gained wider popularity when mobile DNA sequences were shown to comprise about half of the human genome. Although Saccharomyces cerevisiae does not suffer such “genome obesity”, five families of LTR-retrotransposons, Ty1, Ty2, Ty3, Ty4, and Ty5 elements, comprise about 3% of its genome. The availability of complete genome sequences from several Saccharomyces species, including members of the closely related sensu stricto group, present new opportunities for analyzing molecular mechanisms for chromosome evolution, speciation, and reproductive isolation. In this review I present key experiments from both the pre- and current genomic sequencing eras suggesting how Ty elements mediate genome evolution.
© 2005 S. Karger AG, Basel
This work was sponsored by the Center for Cancer Research of the National Cancer Institute, Department of Health and Human Services.
Manuscript received 15 September 2003;
accepted in revised form for publication by J.-N. Volff 3 December 2003.
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 2, Number of References : 62
Cytogenetic and Genome Research
Vol. 110, No. 1-4, Year 2005 (Cover Date: 2005)
Journal Editor: H.P. Klinger, Bronx, N.Y.; M. Schmid, Würzburg
ISSN: 1424–8581 (print), 1424–859X (Online)
For additional information: http://www.karger.com/cgr
Article / Publication Details
Published online: 7/21/2005
Issue release date: 2005
Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2
ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)
For additional information: http://www.karger.com/CGR
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