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Vol. 137, No. 1, 2005
Issue release date: May 2005
Section title: Original Paper
Int Arch Allergy Immunol 2005;137:66–72
(DOI:10.1159/000085106)

Analysis of Growth Factors and Inflammatory Cytokines in Exhaled Breath Condensate from Asthmatic Children

Leung T.-f. · Wong G.W.K. · Ko F.W.S. · Li C.-y. · Yung E. · Lam C.W.K. · Fok T.-f.
Departments of aPaediatrics, bMedicine and Therapeutics, and cChemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/22/2004
Accepted: 1/27/2005
Published online: 5/4/2005

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: Vascular endothelial growth factor (VEGF), AA isoform of platelet-derived growth factor (PDGF-AA), and epidermal growth factor (EGF) are involved in the pathogenesis of airway inflammation in asthma. These molecules are closely associated with cytokines such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-4. This study investigates the relation between childhood asthma and levels of these mediators in exhaled breath condensate (EBC). Methods: EBC was collected from asthmatic children and controls using a disposable collection kit, and the concentrations of VEGF, PDGF-AA, EGF, TNF-α and IL-4 in EBC were measured using sandwich enzyme immunoassays. Exhaled nitric oxide concentration was measured by a chemiluminescence analyzer. Results: Thirty-five asthmatic patients aged between 7 and 18 years and 11 controls were recruited. Sixteen patients had intermittent asthma (IA) whereas 19 of them suffered from persistent asthma (PA). A significant correlation was found between IL-4 and TNF-α in EBC (ρ = 0.374, p = 0.010). PDGF-AA levels in EBC were higher in subjects with diminished FEV1 (p = 0.023) whereas IL-4 concentrations were increased in asthmatics (p = 0.007) as well as subjects with increased plasma total IgE (p = 0.033). Patients with PA receiving high-dose inhaled corticosteroid (ICS) had higher EBC IL-4 concentration than those on low-dose ICS (p = 0.007). Linear regression revealed that PDGF-AA levels in EBC were negatively associated with FEV1 percentage (β = –0.459, p = 0.006) among the asthmatic patients. Conclusions: IL-4 in EBC is increased in childhood asthma, and growth factors are detectable in a significant proportion of these children. Increased PDGF-AA is found in asthmatics with more severe airflow limitation.


  

Author Contacts

Correspondence to: Dr. T.F. Leung
Department of Paediatrics, 6/F, Clinical Sciences Building
Prince of Wales Hospital
Shatin, Hong Kong SAR (China)
Tel. +852 2632 2981, Fax +852 2636 0020, E-Mail leung2142@cuhk.edu.hk

  

Article Information

Received: November 22, 2004
Accepted after revision: January 27, 2005
Published online: April 12, 2005
Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 3, Number of References : 33

  

Publication Details

International Archives of Allergy and Immunology

Vol. 137, No. 1, Year 2005 (Cover Date: May 2005)

Journal Editor: Valenta, R. (Vienna)
ISSN: 1018–2438 (print), 1423–0097 (Online)

For additional information: http://www.karger.com/iaa


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/22/2004
Accepted: 1/27/2005
Published online: 5/4/2005

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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