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Pharmacology and Treatment

Cloxacillin versus Pristinamycin for Superficial Pyodermas: A Randomized, Open-Label, Non-Inferiority Study

Chosidow O.a · Bernard P.d · Berbis P.e · Humbert P.f · Crickx B.b · Jarlier V.b

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aDepartment of Internal Medicine, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris and Université Paris-VI, bDepartment of Dermatology, Hôpital Bichat, and cDepartment of Bacteriology, Hôpital Pitié-Salpêtrière, Paris, dDepartment of Dermatology, Hôpital Robert-Debré, Reims, eDepartment of Dermatology, Hôpital Nord, Marseille, and fDepartment of Dermatology, Hôpital Saint-Jacques, Besançon, France

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Dermatology 2005;210:370–374

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: July 21, 2004
Accepted: October 25, 2004
Published online: May 30, 2005
Issue release date: May 2005

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: Superficial pyodermas may require systemic antibiotics. In a previous open-label trial, oxacillin and pristinamycin achieved similar cure rates, but its design was not truly that of a non-inferiority study. Objectives: To assess the efficacy and safety of oral cloxacillin versus pristinamycin (both 2 g/day) to treat superficial pyodermas. Methods: Multicentre, parallel-group, open-label, randomized non-inferiority trial. Results: French general practitioners in private practice included 334 out-patients (mean age: 42 years). At the follow-up (day 14), the cure rates (primary efficacy end point) for the intent-to-treat populations were 80.7% (138/171) for cloxacillin and 82.8% (135/163) for pristinamycin. The observed difference between cure rates was –2.1%, with the lower limit of the two-sided 95% confidence interval higher than the non-inferiority threshold of –15%. The per-protocol analysis yielded similar results. Therapy was discontinued for 10 patients (cloxacillin: 1, pristinamycin: 9; p = 0.01). Conclusion: Cloxacillin could be an alternative to pristinamycin in out-patients with superficial pyodermas.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: July 21, 2004
Accepted: October 25, 2004
Published online: May 30, 2005
Issue release date: May 2005

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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