Early Life Socioeconomic Status and Late Life Risk of Alzheimer’s DiseaseWilson R.S. · Scherr P.A. · Hoganson G. · Bienias J.L. · Evans D.A. · Bennett D.A.
aRush Alzheimer’s Disease Center, bRush Institute for Healthy Aging, Departments of cNeurological Sciences, dPsychology and eInternal Medicine, Rush University Medical Center, Chicago, Ill., and fthe National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Ga., USA
The authors examined the relation of early life socioeconomic status to incident Alzheimer’s disease (AD), level of cognition and rate of cognitive decline in old age. For up to 10 years, 859 older Catholic clergy members without dementia at baseline completed annual clinical evaluations as part of the Religious Orders Study. The evaluations included clinical classification of AD and detailed cognitive testing. At baseline, indicators of early life household socioeconomic level (e.g., parental education) and the county of birth were ascertained. Socioeconomic features of the birth county (e.g., literacy rate) were estimated with data from the 1920 US Census. Composite measures of early life household and community socioeconomic level were developed. In analyses that controlled for age, sex and education, higher household and community socioeconomic levels in early life were associated with higher level of cognition in late life but not with risk of AD or rate of cognitive decline. The results suggest that early life socioeconomic level is related to level of cognition in late life but not to rate of cognitive decline or risk of AD.
Robert S. Wilson, PhD
Rush Alzheimer’s Disease Center, Rush University Medical Center
600 South Paulina, Suite 1038
Chicago, IL 60612 (USA)
Tel. +1 312 942 2354, Fax +1 312 942 2297, E-Mail firstname.lastname@example.org
Published online: April 25, 2005
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 4, Number of References : 41
Vol. 25, No. 1, Year 2005 (Cover Date: Released June 2005)
Journal Editor: Román, G.C. (San Antonio, Tex.)
ISSN: 0251–5350 (print), 1423–0208 (Online)
For additional information: http://www.karger.com/ned