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Vol. 72, No. 3, 2005
Issue release date: May–June 2005
Section title: Clinical Investigations
Respiration 2005;72:249–253
(DOI:10.1159/000085365)

Surfactant Protein A Detection in Primary Pulmonary Adenocarcinoma without Bronchioloalveolar Pattern

Uzaslan E. · Stuempel T. · Ebsen M. · Freudenberg N. · Nakamura S. · Costabel U. · Guzman J.
aGeneral and Experimental Pathology, University of Bochum, Bochum, bDepartment of Cytology, Institute of Pathology, University of Freiburg i. Br., Freiburg i. Br., cDepartment of Pneumology and Allergy, Ruhrlandklinik, Essen, Germany; dDepartment of General Medicine and Clinical Investigation, Nara Medical University, Nara, Japan

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Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Received: 9/3/2003
Accepted: 8/25/2004
Published online: 6/2/2005

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

Background: Immunohistochemical studies in human lung carcinoma reported positive staining of tumor cells for surfactant protein A (SP-A), especially in peripheral airway cell carcinoma, which include bronchioloalveolar carcinoma and in some reports also papillary subtypes. Objective: The purpose of this study was to determine the SP-A expression in tumor cells of lung adenocarcinoma without a bronchioloalveolar pattern, classified according to the WHO. Methods: In total, 169 primary adenocarcinomas of the lung (109 acinar, 32 solid with mucin, 24 papillary and 4 mucinous) were examined by immunohistochemistry for SP-A expression. Results: Twenty-five percent of acinar, 38% of papillary and 3% of solid adenocarcinoma with mucin showed a positive intracytoplasmic SP-A reaction of the tumor cells. None of the mucinous adenocarcinomas stained for SP-A. This study included the largest number of acinar adenocarcinomas and solid adenocarcinomas with mucin studied for SP-A. We clearly demonstrated that also primary lung adenocarcinoma without a bronchioloalveolar pattern can express SP-A. A positive staining of hyperplastic type II cells surrounding the tumors or entrapped in the tumor could clearly be differentiated from the SP-A-positive stain of tumor cells. Conclusion: These results support the theory that SP-A-producing cells may generate not only bronchioloalveolar and papillary carcinoma, but also other subtypes of lung adenocarcinoma.


  

Author Contacts

Prof. Dr. med. J. Guzman y Rotaeche
c/o Prof. Shinobu Nakamura, Department of General Medicine and Clinical Investigation
Nara Medical University, 840 Shijo
Kashihara, Nara 634-8522 (Japan)
Tel. +81 744 29 8905, Fax +81 744 24 5739, E-Mail josune@naramed-u.ac.jp

  

Article Information

Received: September 3, 2003
Accepted after revision: August 25, 2004
Number of Print Pages : 5
Number of Figures : 4, Number of Tables : 0, Number of References : 22

  

Publication Details

Respiration (International Journal of Thoracic Medicine)

Vol. 72, No. 3, Year 2005 (Cover Date: May-June 2005)

Journal Editor: C.T. Bolliger, Cape Town
ISSN: 0025–7931 (print), 1423–0356 (Online)

For additional information: http://www.karger.com/res


Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Received: 9/3/2003
Accepted: 8/25/2004
Published online: 6/2/2005

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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