The molecular basis of lung carcinogenesis must be understood more fully and exploited to enhance survival rates of patients suffering from lung cancer. In this review we will discuss the major molecular alterations that occur in lung cancer. Emphasis is placed on alterations that occur early during carcinogenesis since they might be relevant for future screening programs. Finally we will shortly review new approaches that are used to study the molecular pathology of lung cancer and how they can be applied in a clinical setting.
© 2005 S. Karger AG, Basel
E.F. Smit, MD, PhD
Department of Pulmonary Medicine, Free University Medical Center
PO Box 7057
NL–1007 MB Amsterdam (The Netherlands)
Tel. +31 20 4444782, Fax +31 20 4444328, E-Mail firstname.lastname@example.org
Supported by NKB Grant No. VU-1748.
Received: November 26, 2003
Accepted after revision: July 29, 2004
Number of Print Pages : 18
Number of Figures : 5, Number of Tables : 1, Number of References : 198
Respiration (International Journal of Thoracic Medicine)
Vol. 72, No. 3, Year 2005 (Cover Date: May-June 2005)
Journal Editor: C.T. Bolliger, Cape Town
ISSN: 0025–7931 (print), 1423–0356 (Online)
For additional information: http://www.karger.com/res
Article / Publication Details
Published online: 6/2/2005
Issue release date: May–June 2005
Number of Print Pages: 18
Number of Figures: 5
Number of Tables: 1
ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)
For additional information: http://www.karger.com/RES
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