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Vol. 30, No. 1, 1998
Issue release date: January–February 1998
Section title: Original Paper
Eur Surg Res 1998;30:8–12
(DOI:10.1159/000008552)

Effect of Fibrin Glue on Small and Large Bowel Anastomoses in the Rat

Shinohara K.a · Kobayashi E.a,b · Yoshida T.a,b · Toyama N.a · Kiyozaki H.a · Fujimura A.b · Miyata M.a
a Department of Surgery, Omiya Medical Center, Jichi Medical School, Omiya, and b Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 1/21/1998
Issue release date: January–February 1998

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: http://www.karger.com/ESR

Abstract

Fibrin glue has been used as a hemostatic and adhesive agent for many years, but its efficacy in digestive surgery is still controversial. In this study, we evaluated the effect of fibrin glue on the healing of the small and large bowel anastomotic portions by measurement of the anastomotic bursting pressure. Further, the efficacy of fibrin glue in preventing intra-abdominal adhesion formation was assessed. Our results indicated that fibrin glue enhanced the resistance towards an elevation of intraluminal pressure in small bowel, but not in large bowel. Concomitantly, the glue did not significantly attenuate postoperative adhesion formation. A sealing action of fibrin glue might protect against bleeding and microleakage, resulting in beneficial effects on small bowel anastomosis.


  

Author Contacts

Eiji Kobayashi, MD, PhD
Department of Clinical Pharmacology
Jichi Medical School, 3311-1 Yakushiji, Kawachi
329-04 Tochigi (Japan)
Tel. +81 285 44 2111, Fax +81 285 44 7562, E-Mail eijikoba@jichi.ac.jp

  

Article Information

Received: Received: July 14, 1997
Accepted: October 7, 1997
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 1, Number of References : 15

  

Publication Details

European Surgical Research (Clinical and Experimental Surgery)
Founded 1969

Vol. 30, No. 1, Year 1998 (Cover Date: January-February 1998)

Journal Editor: K. Messmer, Munich
ISSN: 0014–312X (print), 1421–9921 (Online)

For additional information: http://www.karger.com/journals/esr


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 1/21/1998
Issue release date: January–February 1998

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: http://www.karger.com/ESR


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