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International equine gene mapping workshop report: a comprehensive linkage map constructed with data from new markers and by merging four mapping resourcesPenedo M.C.T.a · Millon L.V.a · Bernoco D.b · Bailey E.c · Binns M.d · Cholewinski G.e · Ellis N.f · Flynn J.g · Gralak B.h · Guthrie A.i · Hasegawa T.j · Lindgren G.k · Lyons L.A.l · Røed K.H.m · Swinburne J.E.n · Tozaki T.o
aVeterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA (USA); bStormont Laboratories, Inc., Woodland, CA (USA); cMH Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY (USA); dThe Royal Veterinary College, London (UK); eHorse Genetic Markers Laboratory, Agricultural University of Poznan (Poland); fUniversity of Sydney, Faculty of Veterinary Science, Centre for Advanced Technologies in Animal Genetics and Reproduction-ReproGen, Camden (Australia); gWeatherby’s Ireland Blood Typing Laboratory, Kildare (Ireland); hInstitute of Genetics and Animal Breeding, PAS, Jastrzebiec, Wolka Kosowska (Poland); iUniversity of Pretoria, Onderstepoort (Republic of South Africa); jJapan Racing Association, Utsunomiya (Japan); kDepartment of Evolutionary Biology and Department of Medical Biochemistry and Microbiology, UppsalaUniversity(Sweden); lDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis,CA(USA); mDepartment of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo (Norway); nAnimal Health Trust, Newmarket (UK); oDepartment of Molecular Genetics, Laboratory of Racing Chemistry, Utsunomiya (Japan)
A comprehensive male linkage map was generated by adding 359 new, informative microsatellites to the International Equine Gene Map half-sibling reference families and by combining genotype data from three independent mapping resources: a full sibling family created at the Animal Health Trust in Newmarket, United Kingdom, eight half-sibling families from Sweden and two half-sibling families from the University of California, Davis. Because the combined data were derived primarily from half-sibling families, only autosomal markers were analyzed. The map was constructed from a total of 766 markers distributed on the 31 equine chromosomes. It has a higher marker density than that of previously reported maps, with 626 markers linearly ordered and 140 other markers assigned to a chromosomal region. Fifty-nine markers (7%) failed to meet the criteria for statistical evidence of linkage and remain unassigned. The map spans 3,740 cM with an average distance of 6.3 cM between markers. Fifty-five percent of the intervals are ≤5 cM and only 3% ≧20 cM. The present map demonstrates the cohesiveness of the different data sets and provides a single resource for genome scan analyses and integration with the radiation hybrid map.
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