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Vol. 51, No. 4, 2005
Issue release date: June 2005
Section title: Original Paper
Neuropsychobiology 2005;51:234–238
(DOI:10.1159/000085725)

Partial Normalization of Serum Brain-Derived Neurotrophic Factor in Remitted Patients after a Major Depressive Episode

Gervasoni N. · Aubry J.-M. · Bondolfi G. · Osiek C. · Schwald M. · Bertschy G. · Karege F.
Department of Psychiatry,aAdult Psychiatry and bNeuropsychiatry Services, Geneva University Hospital, Geneva, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 6/6/2005

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 3

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

We had previously reported decreased serum brain-derived neurotrophic factor (BDNF) levels in depressed patients. In the present study, we tested the hypothesis that antidepressant treatment would normalize serum BDNF levels, at least in a subgroup of patients. Major depressed patients (15 females and 11 males) diagnosed according to DSM-IV criteria and healthy controls (13 females and 13 males) participated in this study. Serum BDNF was assayed with the ELISA method for depressed and remitted patients and the severity of depression was evaluated with the Montgomery-Asberg Depression Rating Scale. An analysis of variance showed that treatment had an effect [F(1, 24) = 4.46, p = 0.045] on the normalization of serum BDNF levels. We also found a correlation between the severity of depression (r = 0.51, p = 0.008), the pretreatment BDNF levels (r = 0.62, p = 0.001) and the difference in serum BDNF levels after antidepressant treatment. These results suggest that antidepressant treatment has a positive effect on serum BDNF levels and support the hypothesis of neurotrophic factor involvement in affective disorders.


  

Author Contacts

Nicola Gervasoni
Service de Psychiatrie Adulte – Programme Dépression
16–18, bd Saint-Georges
CH–1205 Genève (Switzerland)
Tel. +41 22 327 75 93, Fax +41 22 327 75 99, E-Mail Nicola.Gervasoni@hcuge.ch

  

Article Information

Published online: May 12, 2005
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 3, Number of References : 32

  

Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)

Vol. 51, No. 4, Year 2005 (Cover Date: Released June 2005)

Journal Editor: Strik, W. (Bern)
ISSN: 0302–282X (print), 1423–0224 (Online)

For additional information: http://www.karger.com/nps


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 6/6/2005

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 3

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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