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Vol. 20, No. 2-3, 2005
Issue release date: August 2005
Section title: Original Research Article
Dement Geriatr Cogn Disord 2005;20:57–62
(DOI:10.1159/000085856)

Hyperhomocysteinemia Is Associated with Lower Performance on Memory Tasks in Post-Menopausal Women

Clark M.S. · Guthrie J.R. · Dennerstein L.
The Office for Gender and Health, Department of Psychiatry, University of Melbourne, Australia

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 12/17/2004
Published online: 8/19/2005
Issue release date: August 2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Increased levels of total homocysteine (tHcy) have been associated with lower performance on tests of cognitive function, and may be a potential preclinical marker for Alzheimer’s disease. Most reports have focused on older cohorts, but raised tHcy levels, in association with cognitive changes may be occurring in earlier years. Scores for verbal and working memory were compared to plasma homocysteine levels for 200 healthy women aged 56–67 (mean = 60). Smoking, hormone therapy and age were significantly associated with increased levels of tHcy, whilst vitamin B or folate supplements were significantly associated with lower tHcy levels. Hyperhomocysteinemia (>13 µmol/l) was significantly associated with poor performance for combined verbal and working memory, and there was a trend for hyperhomocysteinemia to be associated with the learning trials for 2 word lists, but not for the delayed trial. As hyperhomocysteinemia is associated with memory changes in women aged 56–67, it may be playing a role in the early dementia processes.

© 2005 S. Karger AG, Basel


  

Author Contacts

Dr. Margaret Clark
Office for Gender and Health
University of Melbourne, 4th Floor, 766 Elizabeth St.
Parkville, 3010 (Australia)
Tel. +61 3 8344 4520, Fax +61 3 9347 4127, E-Mail msclark@unimelb.edu.au

  

Article Information

Accepted: December 17, 2004
Published online: May 20, 2005
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 3, Number of References : 45

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 20, No. 2-3, Year 2005 (Cover Date: Released August 2005)

Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/dem


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 12/17/2004
Published online: 8/19/2005
Issue release date: August 2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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