Hyperhomocysteinemia Is Associated with Lower Performance on Memory Tasks in Post-Menopausal WomenClark M.S. · Guthrie J.R. · Dennerstein L.
The Office for Gender and Health, Department of Psychiatry, University of Melbourne, Australia
Increased levels of total homocysteine (tHcy) have been associated with lower performance on tests of cognitive function, and may be a potential preclinical marker for Alzheimer’s disease. Most reports have focused on older cohorts, but raised tHcy levels, in association with cognitive changes may be occurring in earlier years. Scores for verbal and working memory were compared to plasma homocysteine levels for 200 healthy women aged 56–67 (mean = 60). Smoking, hormone therapy and age were significantly associated with increased levels of tHcy, whilst vitamin B or folate supplements were significantly associated with lower tHcy levels. Hyperhomocysteinemia (>13 µmol/l) was significantly associated with poor performance for combined verbal and working memory, and there was a trend for hyperhomocysteinemia to be associated with the learning trials for 2 word lists, but not for the delayed trial. As hyperhomocysteinemia is associated with memory changes in women aged 56–67, it may be playing a role in the early dementia processes.
© 2005 S. Karger AG, Basel
Dr. Margaret Clark
Office for Gender and Health
University of Melbourne, 4th Floor, 766 Elizabeth St.
Parkville, 3010 (Australia)
Tel. +61 3 8344 4520, Fax +61 3 9347 4127, E-Mail email@example.com
Accepted: December 17, 2004
Published online: May 20, 2005
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 3, Number of References : 45
Dementia and Geriatric Cognitive Disorders
Vol. 20, No. 2-3, Year 2005 (Cover Date: Released August 2005)
Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/dem