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Table of Contents
Vol. 27, No. 2-4, 2005
Issue release date: March – August
Section title: Review
Dev Neurosci 2005;27:93–99
(DOI:10.1159/000085980)

Morphogenesis of the Dentate Gyrus: What We Are Learning from Mouse Mutants

Li G. · Pleasure S.J.
Department of Neurology, Programs in Neuroscience, Developmental Biology and Epilepsy Research, University of California, San Francisco, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: July 29, 2004
Accepted: August 29, 2004
Published online: July 19, 2005
Issue release date: March – August

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

Abstract

The dentate gyrus is one of two locations with continuing neurogenesis in adult mammals. While the function of adult neurogenesis is unknown, it is believed that it is involved in learning and memory. For adult neurogenesis to occur, the dentate gyrus must maintain the appropriate precursor cell niche in the subgranular zone, which is likely to be dependent on the developmental mechanisms at play in forming the dentate gyrus. In this review, we graft a molecular framework onto the known neuroanatomic developmental plan by considering the phenotypes of several mouse mutants that have well characterized dentate gyrus developmental abnormalities. This effort reveals that there are at least six distinct developmental steps that need to occur in the formation of the dentate gyrus, which can be associated with specific gene defects: (1) defining the dentate neuroepithelium; (2) forming the primary radial glial scaffolding; (3) radial migration of granule neurons to form the primordial granule cell layer; (4) establishing the precursor pool in the hilus; (5) radial transformation of the tertiary matrix, and (6) differentiation of dentate granule cells. From this analysis, it is clear that some molecular pathways control multiple steps in the development of the dentate gyrus. For example the Wnt pathway (steps 1, 2, 4) and the chemokine receptor CXCR4 (steps 3, 4) are involved in multiple developmental steps, while the neuronal differentiation gene NeuroD (step 6) and the integrin signaling pathway (step 5) are involved only in discrete stages of the dentate gyrus morphogenesis.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review

Received: July 29, 2004
Accepted: August 29, 2004
Published online: July 19, 2005
Issue release date: March – August

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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