Cover

Cellular Stress Responses in Renal Diseases

Editor(s): Razzaque M.S. (Boston, Mass.) 
Taguchi T. (Nagasaki) 
Table of Contents
Vol. 148, No. , 2005
Section title: Paper
Razzaque MS, Taguchi T (eds): Cellular Stress Responses in Renal Diseases. Contrib Nephrol. Basel, Karger, 2005, vol 148, pp 107-121
(DOI:10.1159/000086055)

Cisplatin-Associated Nephrotoxicity and Pathological Events

Taguchi T.a · Nazneen A.a · Abid M.b · Razzaque M.S.a,c
aDepartment of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; bDivision of Molecular and Vascular Medicine, Department of Medicine, and Vascular Biology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass., USA; cDepartment of Oral and Developmental Biology, Harvard School of Dental Medicine, Boston, Mass., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 5/24/2005
Cover Date: 2005

Number of Print Pages: 15
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-7858-5 (Print)
eISBN: 978-3-318-01170-8 (Online)

Abstract

Cisplatin (cis-diamminedichloroplatinum(II)) is an effective chemotherapeutic agent, and is successfully used in the treatment of a wide range of tumors. Despite its effectiveness as an anti-tumor drug, nephrotoxic side effects have significantly restricted its clinical use. Tubular epithelial cell deletion following cisplatin treatment is a major cause of renal injury. Oxidative stress significantly contributes to cisplatin-associated cytotoxicity, and use of antioxidants could counteract such cytotoxic effects of cisplatin. The renal microenvironmental changes following cisplatin treatment is a complex process and could be broadly categorized into three main pathological events, which at times might overlap: initial cytotoxic events, inflammatory events and fibroproliferative events. Stress responses and heat shock proteins generated following cisplatin treatment are actively involved in the initiation and progression of these events. In this article, we will briefly summarize factors involved in various phases of cisplatin-induced renal injuries.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 5/24/2005
Cover Date: 2005

Number of Print Pages: 15
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-7858-5 (Print)
eISBN: 978-3-318-01170-8 (Online)


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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