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Vol. 53, No. 4, 2005
Issue release date: July 2005
Section title: Original Paper
Eur Neurol 2005;53:188–193
(DOI:10.1159/000086355)

Assessment of Relations between Clinical Outcome of Ischemic Stroke and Activity of Inflammatory Processes in the Acute Phase Based on Examination of Selected Parameters

Palasik W.a · Fiszer U.a · Lechowicz W.b · Czartoryska B.c · Krzesiewicz M.a · Lugowska A.c
Departments of aNeurology and Epileptology, Center for Medical Postgraduate Education, and bNeuropathology and cGenetics, Institute of Psychiatry and Neurology, Warsaw, Poland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/2/2004
Accepted: 4/4/2005
Published online: 7/29/2005
Issue release date: July 2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

Background and Purposes: Inflammatory factors play an important role in the pathogenesis of ischemic stroke. They may influence circulation during the acute phase of stroke and enhance the ischemic region. Materials and Methods: We examined 51 patients – 36 patients in the early stage of stroke, i.e. the first 24 h after onset. Of these, 15 patients had infection and 21 had no infection during the week preceding stroke. There were 15 patients with noninflammatory diseases in the control group. We analyzed parameters of inflammation such as: activity of serum chitotriosidase by fluorimetric assay, C-reactive proteins (CRP), number of white body cells (WBCs), IgG and fibrinogen. We also assessed the neurological stage according to the Scandinavian Stroke Scale (SSS). Results: In our study, we observed a statistically significant difference (p < 0.05) in the activity of most parameters of inflammation. This difference could be seen in the levels of CRP, number of WBCs and the activity of chitotriosidase, apart from IgG and fibrinogen, between the control group and groups with versus without infection. A significantly increased level of CRP (p < 0.0005) and fibrinogen (p > 0.01) was found on the first day in the stroke group as compared to the control group. The neurological stage on day 4 after stroke, assessed according to the SSS, was significantly worse in the group of patients with infection before stroke than in stroke patients without infection (p < 0.008). Conclusion: These results suggest the importance of active inflammatory processes in the pathogenesis of stroke. We observed increased activity of chitotioridase, a parameter of the inflammatory process, in stroke. This study is one more proof that inflammatory processes caused by infection may influence the occurrence of stroke and worsen its outcome. It could be another step towards understanding immunological processes during the acute phase of stroke. The study may also help establish new diagnostic and therapeutic strategies and could be a useful tool for prophylaxis.

© 2005 S. Karger AG, Basel


  

Author Contacts

Witold Palasik
Department of Neurology and Epileptology, Center for Medical Postgraduate Education
Czerniakowska 231
PL–00-416 Warsaw (Poland)
Tel. +48 22 629 43 49, Fax +48 22 625 10 14, E-Mail witpal2@wp.pl

  

Article Information

Received: September 2, 2004
Accepted: April 4, 2005
Published online: June 14, 2005
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 2, Number of References : 27

  

Publication Details

European Neurology

Vol. 53, No. 4, Year 2005 (Cover Date: Released July 2005)

Journal Editor: Bogousslavsky, J. (Lausanne)
ISSN: 0014–3022 (print), 1421–9913 (Online)

For additional information: http://www.karger.com/ene


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/2/2004
Accepted: 4/4/2005
Published online: 7/29/2005
Issue release date: July 2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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