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Table of Contents
Vol. 20, No. 2-3, 2005
Issue release date: August 2005
Section title: Original Research Article
Dement Geriatr Cogn Disord 2005;20:99–104
(DOI:10.1159/000086474)

Acquired Sociopathy and Frontotemporal Dementia

Mendez M.F.a, b · Chen A.K.b · Shapira J.S.a · Miller B.L.c
aDepartments of Neurology and Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, bV.A. Greater Los Angeles Healthcare Center, Los Angeles, and cDepartment of Neurology, University of California at San Francisco, San Francisco, USA

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: March 06, 2005
Published online: August 19, 2005
Issue release date: August 2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background: It is not understood why some patients withfrontotemporal dementia (FTD) manifest sociopathic behavior. Objective: To examine the prevalence and characteristics of sociopathic behavior in FTD patients as compared to those with Alzheimer’s disease (AD). Methods and Participants: We surveyed a group of FTD patients and a group of AD patients for sociopathic behavior, evaluated the characteristics surrounding their acts, and compared the groups on neuropsychological tests and functional neuroimaging. Twenty-eight outpatients with FTD (15 men, 13 women; 61.9 ± 7.1 years; Mini-Mental State Examination score 23.6 ± 8.1) were compared with 28 patients with clinically probable AD (13 men, 15 women; 66.1 ± 9.2 years; Mini-Mental State Examination score 21.3 ± 5.3). Main outcome measures included: (a) the prevalence of sociopathic acts; (b) a structured interview; (c) neuropsychological tests including the Frontal Assessment Battery, and (d) clinically obtained positron emission tomography or single photon emission tomography scans. Results: Sixteen (57%) of the FTD patients had sociopathic behavior compared to two (7%) of the AD patients (χ2 = 13.84, p < 0.001). Sociopathic acts among FTD patients included unsolicited sexual acts, traffic violations, physical assaults, and other unacceptable behaviors. On interview, the FTD patients with sociopathic acts were aware of their behavior and knew that it was wrong but could not prevent themselves from acting impulsively. They claimed subsequent remorse, but they did not act on it or show concern for the consequences. Among FTD patients with sociopathy, neuropsychological assessment showed impaired motor inhibition, and functional neuroimaging showed right frontotemporal involvement. Conclusion: The results suggest that sociopathy in FTD results from a combination of diminished emotional concern for the consequences of their acts and disinhibition consequent to right frontotemporal dysfunction. In many jurisdictions, FTD patients with sociopathy would not pass legal criteria for ‘not guilty by reason of insanity’.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: March 06, 2005
Published online: August 19, 2005
Issue release date: August 2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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