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Vol. 20, No. 5, 2005
Issue release date: September–October 2005
Section title: Paper
Fetal Diagn Ther 2005;20:420–425
(DOI:10.1159/000086824)

The Role of RCAS1 and Oxytocinase in Immune Tolerance during Pregnancy

Wicherek L. · Dutsch-Wicherek M. · Mak P. · Klimek M.
Department of Gynecology and Infertility of Jagiellonian University, Krakow, Poland

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 4/7/2004
Accepted: 7/27/2004
Published online: 8/19/2005
Issue release date: September–October 2005

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT

Abstract

Objectives: To determine and compare the level of RCAS1 (receptor-binding cancer antigen expressed in SiSo cells) in placentas at term as well as oxytocinase/cystine amino peptidase (CAP) serum level a few days before labor in order to evaluate their possible role in the regulation of maternal immune response during pregnancy and in initiation of labor. Methods: We estimated the RCAS1 content in 44 placental tissue samples, using Western blot method. We also assessed CAP serum level by its enzymatic activity, using L-cystine-di-β-naphthylamide as a synthetic substrate. The statistical analysis was performed using Shapiro-Wilk procedure. Student’s t test was applied to compare the differences between parametric data. A value of p < 0.05 was considered significant. Results: RCAS1 was found in all placental tissue samples examined. The differences in the RCAS1 relative amount depended on the onset of labor, with the highest level in induced labor and the lowest in spontaneous labor. The differences were also observed in the CAP serum level with the highest level in pregnant women whose labor was induced. Conclusions: We have observed a link between the expression of the two proteins examined and the onset of the labor. Therefore, we posit that RCAS1 and CAP may play a role in the downregulation of the maternal immune response during pregnancy and may participate in the initiation of the labor.

© 2005 S. Karger AG, Basel


  

Author Contacts

L. Wicherek
Department of Gynecology and Infertility of Jagiellonian University
23 Kopernika Street
PL–30-005 Krakow (Poland)
Tel./Fax +48 12 424 85 85, E-Mail mowicher@cyf-kr.edu.pl

  

Article Information

Received: April 7, 2004
Accepted after revision: July 27, 2004
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 2, Number of References : 24

  

Publication Details

Fetal Diagnosis and Therapy (Clinical Advances and Basic Research)

Vol. 20, No. 5, Year 2005 (Cover Date: September-October 2005)

Journal Editor: Holzgreve, W. (Basel)
ISSN: 1015–3837 (print), 1421–9964 (Online)

For additional information: http://www.karger.com/fdt


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 4/7/2004
Accepted: 7/27/2004
Published online: 8/19/2005
Issue release date: September–October 2005

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT


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