Journal Mobile Options
Table of Contents
Vol. 26, No. 4, 2005
Issue release date: July–August 2005
Section title: Research Article
Tumor Biol 2005;26:195–200
(DOI:10.1159/000086952)

Enhanced Expression of Aggrus (T1alpha/Podoplanin), a Platelet-Aggregation-Inducing Factor in Lung Squamous Cell Carcinoma

Kato Y. · Kaneko M. · Sata M. · Fujita N. · Tsuruo T. · Osawa M.
aDepartment of Experimental and Forensic Pathology and bFirst Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, and cInstitute of Molecular and Cellular Biosciences, University of Tokyo, and dCancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: 11/27/2004
Accepted: 2/11/2005
Published online: 7/29/2005

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 0

ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)

For additional information: http://www.karger.com/TBI

Abstract

Aggrus (T1α/podoplanin, known as a specific marker for type I alveolar cells or lymphatic endothelial cells) is a transmembrane sialoglycoprotein that aggregates platelets. Previously, we showed that upregulated expression of Aggrus occurs in colorectal tumors or testicular tumors and could be associated with platelet-aggregating activity and metastatic ability. In testicular tumors, Aggrus is specifically expressed in seminoma. The present study investigates Aggrus expression in human primary lung cancer tissues of different types. Microarray analysis demonstrated that aggrus was significantly expressed in squamous cell carcinoma (10/15; 66.7%). Immunohistochemical analysis also showed that the incidence of positive staining in sections of squamous cell carcinoma (7/8; 87.5%) was higher than that in adenocarcinoma (2/13; 15.4%). Furthermore, Aggrus expression was detected in a squamous cell carcinoma cell line, NCI-H226, by real-time PCR. These findings indicated that overexpression of Aggrus occurred in squamous cell carcinoma of the lung. Therefore, Aggrus could be a useful diagnostic marker for squamous cell carcinoma of the lung.


  

Author Contacts

Mika Kaneko, PhD, Department of Developmental Neuroscience
Tokyo Metropolitan Institute for Neuroscience
2-6 Musashidai, Fuchu, Tokyo 183-8526 (Japan)
Tel. +81 42 325 3881, Fax +81 42 321 8678
E-Mail mkaneko@tmin.ac.jp or mikanekok@hotmail.com

  

Article Information

Received: November 27, 2004
Accepted after revision: February 11, 2005
Published online: July 7, 2005
Number of Print Pages : 6
Number of Figures : 4, Number of Tables : 0, Number of References : 24

  

Publication Details

Tumor Biology (Tumor Markers, Tumor Targeting and Translational Cancer Research)

Vol. 26, No. 4, Year 2005 (Cover Date: July-August 2005)

Journal Editor: Stigbrand, T. (Umeå)
ISSN: 1010–4283 (print), 1423–0380 (Online)

For additional information: http://www.karger.com/tbi


Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: 11/27/2004
Accepted: 2/11/2005
Published online: 7/29/2005

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 0

ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)

For additional information: http://www.karger.com/TBI


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.