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Table of Contents
Vol. 26, No. 4, 2005
Issue release date: July – August
Section title: Research Article
Tumor Biol 2005;26:213–216
(DOI:10.1159/000086955)

Expression of the Breast Cancer Metastasis Suppressor Gene, BRMS1, in Human Breast Carcinoma: Lack of Correlation with Metastasis to Axillary Lymph Nodes

Kelly L.M. · Buggy Y. · Hill A. · O’Donovan N. · Duggan C. · McDermott E.W. · O’Higgins N.J. · Young L. · Duffy M.J.
Department of Surgery, Medical Oncology and Nuclear Medicine, St. Vincent’s University Hospital and Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland

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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: October 16, 2004
Accepted: March 16, 2005
Published online: July 29, 2005
Issue release date: July – August

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)

For additional information: http://www.karger.com/TBI

Abstract

The BRMS1 (breast cancer metastasis suppressor 1) gene has been found to suppress metastasis in animal models without inhibiting primary tumor growth. The aim of this study was to measure expression of BRMS1 mRNA in a panel of human breast carcinomas and compare its expression with parameters of local dissemination such as tumor size and lymph node metastasis. We also compared expression of BRMS1 mRNA in normal breast tissue, fibroadenomas, primary breast cancers and axillary nodal metastases from primary breast cancers. BRMS1 mRNA was detected in 10/11 (90%) specimens of normal breast tissue, 12/16 (75%) fibroadenomas, 64/82 (78%) primary breast cancer and 11/15 (64%) lymph node metastases (p, NS). In the primary cancer, expression was independent of tumor size, tumor grade, metastasis to axillary nodes and hormone receptor status. Furthermore, similar levels of BRMS1 were found in normal breast tissue, primary breast carcinomas and lymph node metastases from primary breast cancer. Our results do not suggest a role for BRMS1 in suppressing metastasis to local lymph nodes in patients with breast cancer.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: October 16, 2004
Accepted: March 16, 2005
Published online: July 29, 2005
Issue release date: July – August

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)

For additional information: http://www.karger.com/TBI


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