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Table of Contents
Vol. 114, Suppl. 1, 2005
Issue release date: September 2005
Section title: Paper
Acta Haematol 2005;114:8–13
(DOI:10.1159/000087038)

Future Directions in Multiple Myeloma Treatment

Child J.A.a · Russell N.b · Sonneveld P.c · Schey S.d
aGeneral Infirmary and University of Leeds, Leeds; bMolecular Medical Sciences, Division of Haematology, Nottingham University Medical School, Nottingham, UK; cErasmus Medical Center Rotterdam, Rotterdam, The Netherlands; dGuy’s Hospital, St. Thomas’ Street, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: September 15, 2005
Issue release date: September 2005

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

Future therapy options for multiple myeloma may be directed at asymptomatic disease, as only symptomatic myeloma is treated currently. Additional genetic information from gene array analysis will mean that the identification of cases with poor prognosis will become more sophisticated. New markers are being discovered constantly, and these continuously change the picture regarding prognostic factors. More intensive treatment options increase the depth of remissions, thereby improving outcomes. In pilot studies, cyclophosphamide, thalidomide and dexamethasone (CTD) was a highly effective, well-tolerated regimen for patients refractory to initial therapy with VAD or with relapsed disease. It is being further evaluated as induction therapy in the current MRC Myeloma IX trial. Also under investigation is a small molecule derivative of thalidomide, CC-4047 (Actimid). It has between 1,000 and 10,000 times more potent antitumour necrosis factor alpha activity, with an additional immunomodulatory effect. It has been shown to be between 50 and 2,000 times more potent in the stimulation of T-cell proliferation and 50–100 times more potent in augmenting interleukin-2 and interferon-γ production. With many possible approaches to study and work through, future strategies will revolve around exploration of the effectiveness of combinations that incorporate new agents in various disease and treatment settings. The use of genetic profiles to further delineate groups for different treatment approaches should enable the introduction of patient-specific treatment programmes in the future.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: September 15, 2005
Issue release date: September 2005

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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