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Table of Contents
Vol. 49, No. 1-2, 2006
Issue release date: September 2005
Section title: Epidemiology
Intervirology 2006;49:28–36
(DOI:10.1159/000087260)

Spread Times of Hepatitis C Virus Estimated by the Molecular Clock Differ among Japan, the United States and Egypt in Reflection of Their Distinct Socioeconomic Backgrounds

Mizokami M.a · Tanaka Y.a · Miyakawa Y.b
aDepartment of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, and bMiyakawa Memorial Research Foundation, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Epidemiology

Published online: September 16, 2005
Issue release date: September 2005

Number of Print Pages: 9
Number of Figures: 7
Number of Tables: 1

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT

Abstract

Infection with hepatitis C virus (HCV) is taking an ever increasing role in the development of hepatocellular carcinoma (HCC) over the world. Dynamics of HCV infection were determined by the molecular clock, estimating the dissemination time when HCV entered the country and the ‘spread time’ when it started to grow exponentially on a national scale. A comparison of HCV dynamics in Japan, the United States and Egypt has disclosed different dissemination and spread times among the three countries. Furthermore, they faithfully mirror socioeconomic as well as medical and paramedical events inherent to each country responsible for the wide spread of HCV infection during the past. Epidemic histories of HCV would enable us to predict what is going to happen in the future for HCV infection, in special reference to HCC associated with it. Population dynamics of HCV need to be determined in other countries where HCV prevails and compared with those in the three countries described. These studies should help foresee what will happen in the near future for HCV infection in a given country, time the future development of HCC and take measures for preventing it.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Epidemiology

Published online: September 16, 2005
Issue release date: September 2005

Number of Print Pages: 9
Number of Figures: 7
Number of Tables: 1

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.