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Vol. 49, No. 1-2, 2006
Issue release date: 2006
Section title: Epidemiology
Intervirology 2006;49:28–36
(DOI:10.1159/000087260)

Spread Times of Hepatitis C Virus Estimated by the Molecular Clock Differ among Japan, the United States and Egypt in Reflection of Their Distinct Socioeconomic Backgrounds

Mizokami M.a · Tanaka Y.a · Miyakawa Y.b
aDepartment of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, and bMiyakawa Memorial Research Foundation, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Epidemiology

Published online: 9/16/2005
Issue release date: 2006

Number of Print Pages: 9
Number of Figures: 7
Number of Tables: 1

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT

Abstract

Infection with hepatitis C virus (HCV) is taking an ever increasing role in the development of hepatocellular carcinoma (HCC) over the world. Dynamics of HCV infection were determined by the molecular clock, estimating the dissemination time when HCV entered the country and the ‘spread time’ when it started to grow exponentially on a national scale. A comparison of HCV dynamics in Japan, the United States and Egypt has disclosed different dissemination and spread times among the three countries. Furthermore, they faithfully mirror socioeconomic as well as medical and paramedical events inherent to each country responsible for the wide spread of HCV infection during the past. Epidemic histories of HCV would enable us to predict what is going to happen in the future for HCV infection, in special reference to HCC associated with it. Population dynamics of HCV need to be determined in other countries where HCV prevails and compared with those in the three countries described. These studies should help foresee what will happen in the near future for HCV infection in a given country, time the future development of HCC and take measures for preventing it.

© 2006 S. Karger AG, Basel


  

Author Contacts

Masashi Mizokami, MD
Department of Clinical Molecular Informative Medicine
Nagoya City University Graduate School of Medical Sciences
Nagoya 467-8601 (Japan)
Tel. +81 52 853 8292, Fax +81 52 842 0021, E-Mail mizokami@med.nagoya-cu.ac.jp

  

Article Information

Number of Print Pages : 9
Number of Figures : 7, Number of Tables : 1, Number of References : 41

  

Publication Details

Intervirology (International Journal of Basic and Medical Virology)

Vol. 49, No. 1-2, Year 2006 (Cover Date: 2006)

Journal Editor: Liebert, U.G. (Leipzig)
ISSN: 0300–5526 (print), 1423–0100 (Online)

For additional information: http://www.karger.com/int


Article / Publication Details

First-Page Preview
Abstract of Epidemiology

Published online: 9/16/2005
Issue release date: 2006

Number of Print Pages: 9
Number of Figures: 7
Number of Tables: 1

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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