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Table of Contents
Vol. 49, No. 1-2, 2006
Issue release date: September 2005
Section title: Hepatocellular Carcinoma
Intervirology 2006;49:76–81
(DOI:10.1159/000087267)

Viral Etiology of Hepatocellular Carcinoma and HCV Genotypes in Taiwan

Lee C.-M.a · Hung C.-H.a · Lu S.-N.a · Wang J.-H.a · Tung H.-D.a · Huang W.-S.a · Chen C.-L.b · Chen W.-J.c · Changchien C.-S.a
aDivision of Hepatogastroenterology, Department of Internal Medicine, and Departments of

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Article / Publication Details

First-Page Preview
Abstract of Hepatocellular Carcinoma

Published online: September 16, 2005
Issue release date: September 2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT

Abstract

Etiologic variations of hepatocellular carcinoma (HCC) exist in different geographic areas of the world. Hepatitis B virus infection is associated with HCC. However, hepatitis C virus (HCV) infection plays an increasingly more important role in the development of HCC and is associated with more than 30% of HCC in Taiwan. The prevalence of HCV infection and HCV genotypes vary in different geographic areas. The prevalence of HCV genotype 1b (HCV-1b) was around 50–70% in Taiwan and even varied in different townships. In addition to host factors, HCV genotypes may be associated with the development of HCC. In our study, the prevalence of HCV-1b in patients with HCC was significantly higher than in those with liver cirrhosis and chronic hepatitis; multivariate analysis revealed that the disease severity was significantly correlated with age and HCV-1b. Furthermore, HCV-1b was associated with a lower response rate to interferon (IFN) therapy than HCV-2. Our study has demonstrated that mutations in the IFN sensitivity-determining region, spanning nucleotides 2,209–2,248 in the NS5A region, correlate with the sustained virological response to combination therapy with IFN and ribavirin in patients with chronic HCV-1b infection in Taiwan. A third-generation enzyme immunoassay for antibody to HCV can be used to predict viremia and monitor the virological response.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Hepatocellular Carcinoma

Published online: September 16, 2005
Issue release date: September 2005

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


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