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Table of Contents
Vol. 20, No. 4, 2005
Issue release date: September 2005
Section title: Original Research Article
Dement Geriatr Cogn Disord 2005;20:254–261
(DOI:10.1159/000087371)

Apolipoprotein E ε4 Allele Differentiates the Clinical Response to Donepezil in Alzheimer’s Disease

Bizzarro A.a · Marra C.a · Acciarri A.a · Valenza A.a · Tiziano F.D.b · Brahe C.b · Masullo C.a
aInstitutes of Neurology, and bMedical Genetics, Catholic University of Sacred Heart, School of Medicine, Rome, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: June 02, 2005
Published online: September 12, 2005
Issue release date: September 2005

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

The existence of an association between apolipoprotein E (APOE) and Alzheimer’s disease (AD) has been reported in several studies. The possession of an ApoE ε4 allele is now considered a genetic risk factor for sporadic AD. There has been a growing agreement about the role exerted by the ApoE ε4 allele on the neuropsychological profile and the rate of cognitive decline in AD patients. However, a more controversial issue remains about a possible influence of the APOE genotype on acetylcholinesterase inhibitor therapy response in AD patients. In order to address this issue, 81 patients diagnosed as having probable AD were evaluated by a complete neuropsychological test battery at the time of diagnosis (baseline) and after 12–16 months (retest). Patients were divided into two subgroups: (1) treated with donepezil at a dose of 5 mg once a day (n = 41) and (2) untreated (n = 40). Donepezil therapy was started after baseline evaluation. The APOE genotype was determined according to standardized procedures. We evaluated the possible effect of the APOE genotype on the neuropsychological tasks in relation to donepezil therapy. The statistical analysis of the results showed a global worsening of cognitive performances for all AD patients at the retest. Differences in the clinical outcome were analysed in the four subgroups of AD patients for each neuropsychological task. ApoE ε4 carriers/treated patients had improved or unchanged scores at retest evaluation for the following tasks: visual and verbal memory, visual attention and inductive reasoning and Mini Mental State Examination. These results indicate an effect of donepezil on specific cognitive domains (attention and memory) in the ApoE ε4 carriers with AD. This might suggest an early identification of AD patients carrying at least one ε4 allele as responders to donepezil therapy.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: June 02, 2005
Published online: September 12, 2005
Issue release date: September 2005

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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