When activated by diverse stimuli, mast cells mobilize arachidonic acid through cytosolic
, and rapidly generate both prostaglandin D2
and leukotriene C4
, the parent
molecule of the cysteinyl LTs. While initially recognized for their bronchoconstricting and
vasoactive properties, these two eicosanoids are now known to serve diverse and pivotal
functions in effector cell trafficking, antigen presentation, immune cell activation, matrix
deposition, and fibrosis. This chapter reviews the biological functions for each eicosanoid
and their respective receptor classes, discusses the mechanisms by which the generation of
eicosanoids by mast cells is regulated, and considers the potential pathobiologic and therapeutic
ramifications in host defense, inflammation, and allergic diseases.
Copyright / Drug Dosage
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