Cover

Mast Cells in Allergic Diseases

Editor(s): Saito H. (Tokyo) 
Okayama Y. (Yokohama) 
Table of Contents
Vol. 87, No. , 2005
Section title: Paper
Saito H, Okayama Y (eds): Mast Cells in Allergic Diseases. Chem Immunol Allergy. Basel, Karger, 2005, vol 87, pp 59-79
(DOI:10.1159/000087571)

Eicosanoid Mediators of Mast Cells: Receptors, Regulation of Synthesis, and Pathobiologic Implications

Boyce J.
Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, Mass., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 8/15/2005
Cover Date: 2005

Number of Print Pages: 21
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-7948-3 (Print)
eISBN: 978-3-318-01232-3 (Online)

Abstract

When activated by diverse stimuli, mast cells mobilize arachidonic acid through cytosolic phospholipase A2, and rapidly generate both prostaglandin D2 and leukotriene C4, the parent molecule of the cysteinyl LTs. While initially recognized for their bronchoconstricting and vasoactive properties, these two eicosanoids are now known to serve diverse and pivotal functions in effector cell trafficking, antigen presentation, immune cell activation, matrix deposition, and fibrosis. This chapter reviews the biological functions for each eicosanoid and their respective receptor classes, discusses the mechanisms by which the generation of eicosanoids by mast cells is regulated, and considers the potential pathobiologic and therapeutic ramifications in host defense, inflammation, and allergic diseases.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 8/15/2005
Cover Date: 2005

Number of Print Pages: 21
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-7948-3 (Print)
eISBN: 978-3-318-01232-3 (Online)


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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