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Table of Contents
Vol. 18, No. 6, 2005
Issue release date: November–December 2005
Section title: Review
Skin Pharmacol Appl Skin Physiol 2005;18:253–262
(DOI:10.1159/000087606)

Sunscreens – Which and What for?

Maier T. · Korting H.C.
Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: 12/13/2004
Accepted: 5/13/2005
Published online: 10/19/2005

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

It is well established that sun exposure is the main cause for the development of skin cancer. Chronic continuous UV radiation is believed to induce malignant melanoma, whereas intermittent high-dose UV exposure contributes to the occurrence of actinic keratosis as precursor lesions of squamous cell carcinoma as well as basal cell carcinoma. Not only photocarcinogenesis but also the mechanisms of photoaging have recently become apparent. In this respect the use of sunscreens seemed to prove to be more and more important and popular within the last decades. However, there is still inconsistency about the usefulness of sunscreens. Several studies show that inadequate use and incomplete UV spectrum efficacy may compromise protection more than previously expected. The sunscreen market is crowded by numerous products. Inorganic sunscreens such as zinc oxide and titanium oxide have a wide spectral range of activity compared to most of the organic sunscreen products. It is not uncommon for organic sunscreens to cause photocontact allergy, but their cosmetic acceptability is still superior to the one given by inorganic sunscreens. Recently, modern galenic approaches such as micronization and encapsulation allow the development of high-quality inorganic sunscreens. The potential systemic toxicity of organic sunscreens has lately primarily been discussed controversially in public, and several studies show contradictory results. Although a matter of debate, at present the sun protection factor (SPF) is the most reliable information for the consumer as a measure of sunscreen filter efficacy. In this context additional tests have been introduced for the evaluation of not only the protective effect against erythema but also protection against UV-induced immunological and mutational effects. Recently, combinations of UV filters with agents active in DNA repair have been introduced in order to improve photoprotection. This article reviews the efficacy of sunscreens in the prevention of epithelial and nonepithelial skin cancer, the effect on immunosuppression and the value of the SPF as well as new developments on the sunscreen market.


  

Author Contacts

Dr. Tanja Maier
Department of Dermatology and Allergology
Ludwig Maximilian University, Frauenlobstrasse 9–11
DE–80337 Munich (Germany)
Tel. +49 89 5160 6010, Fax +49 89 5160 6110, E-Mail Tanja.Maier@med.uni-muenchen.de

  

Article Information

Received: December 13, 2004
Accepted after revision: May 13, 2005
Published online: August 19, 2005
Number of Print Pages : 10
Number of Figures : 5, Number of Tables : 1, Number of References : 56

  

Publication Details

Skin Pharmacology and Physiology (Journal of Pharmacological and Biophysical Research)

Vol. 18, No. 6, Year 2005 (Cover Date: November-December 2005)

Journal Editor: Lademann, J. (Berlin)
ISSN: 1660–5527 (print), 1660–5535 (Online)

For additional information: http://www.karger.com/spp


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 12/13/2004
Accepted: 5/13/2005
Published online: 10/19/2005

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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