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Vol. 72, No. 1, 2005
Issue release date: 2005
Section title: Review
Digestion 2005;72:51–56
(DOI:10.1159/000087637)

Is Lactobacillus rhamnosus GG Effective in Preventing the Onset of Antibiotic-Associated Diarrhoea: A Systematic Review

Hawrelak J.A. · Whitten D.L. · Myers S.P.
aSchool of Natural and Complementary Medicine, Southern Cross University, Lismore, and bAustralian Centre for Complementary Medicine Education and Research, University of Queensland and Southern Cross University, Lismore, Australia

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 9/9/2005

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 4

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

Objective: To evaluate the efficacy of Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea. Data Sources: A computer-based search of MEDLINE, CINAHL, AMED, the Cochrane Controlled Trials Register and the Cochrane Database of Systematic Reviews was conducted. A hand-search of the bibliographies of relevant papers and previous meta-analyses was undertaken. Review Methods: Trials were included in the review if they compared the effects of L. rhamnosus GG and placebo and listed diarrhoea as a primary end-point. Studies were excluded if they were not placebo-controlled or utilised other probiotic strains. Results: Six trials were found that met all eligibility requirements. Significant statistical heterogeneity of the trials precluded meta-analysis. Four of the six trials found a significant reduction in the risk of antibiotic-associated diarrhoea with co-administration of Lactobacillus GG. One of the trials found a reduced number of days with antibiotic-induced diarrhoea with Lactobacillus GG administration, whilst the final trial found no benefit of Lactobacillus GG supplementation. Conclusion: Additional research is needed to further clarify the effectiveness of Lactobacillus GG in the prevention of antibiotic-associated diarrhoea.


  

Author Contacts

J.A. Hawrelak
School of Natural and Complementary Medicine, Southern Cross University
PO Box 157
Lismore, NSW 2480 (Australia)
Tel. +61 2 6620 3308, Fax +61 2 6620 3307, E-Mail jhawre10@scu.edu.au

  

Article Information

Published online: August 18, 2005
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 4, Number of References : 23

  

Publication Details

Digestion (International Journal of Gastroenterology)

Vol. 72, No. 1, Year 2005 (Cover Date: 2005)

Journal Editor: Beglinger, C. (Basel)
ISSN: 0012–2823 (print), 1421–9867 (Online)

For additional information: http://www.karger.com/dig


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 9/9/2005

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 4

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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