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Vol. 72, No. 5, 2005
Issue release date: September–October 2005
Section title: Clinical Investigations
Respiration 2005;72:486–489
(DOI:10.1159/000087672)

C-Reactive Protein in Lymphocytic Pleural Effusions: A Diagnostic Aid in Tuberculous Pleuritis

Garcia-Pachon E. · Soler M.J. · Padilla-Navas I. · Romero V. · Shum C.
Section of Pneumology, Hospital General Universitario, Elche, Spain

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Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Received: 7/9/2004
Accepted: 10/25/2004
Published online: 9/16/2005

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 2

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

Background:C-reactive protein (CRP) pleural fluid levels have been found to be higher in tuberculosis and parapneumonic effusions than in other causes of pleural effusion. Objective:The aim of this study was to analyze whether CRP (a simple and inexpensive test) may be a diagnostic aid for tuberculosis in lymphocytic pleural effusions. Methods:One hundred and forty-four patients with a lymphocytic pleural effusion (more than 50% lymphocytes in the differential white blood cell count) were included. The patients were 93 men (65%) and 51 women (35%), aged 64 ± 18 years (mean ± SD). The diagnoses were as follows: tuberculosis, 20; pleural effusion associated with malignancy, 69; transudates, 38; other benign exudates, 17. Results: The CRP pleural fluid level was higher in tuberculous pleuritis (54 ± 24 mg/l) than in lymphocytic effusions of other origin (21 ± 16 mg/l; p < 0.001). High CRP levels (≧50 mg/l) have a high specificity for tuberculosis (95%), and low levels (<30 mg/l) have a high sensitivity (95%) for excluding disease. Conclusions: CRP pleural fluid level determination is useful in the diagnostic workup of lymphocytic pleural effusions. High CRP levels are very suggestive of tuberculous pleuritis, and low CRP levels make this diagnosis unlikely.


  

Author Contacts

Eduardo Garcia-Pachon, MD
Section of Pneumology, Hospital General Universitario
ES–03203 Elche, Alicante (Spain)
Tel. +34 96 667 90 00, Fax +34 96 667 91 08, E-Mail egpachon@hotmail.com

  

Article Information

Received: July 9, 2004
Accepted after revision: October 25, 2004
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 2, Number of References : 30

  

Publication Details

Respiration (International Journal of Thoracic Medicine)

Vol. 72, No. 5, Year 2005 (Cover Date: September-October 2005)

Journal Editor: Bolliger, C.T. (Cape Town)
ISSN: 0025–7931 (print), 1423–0356 (Online)

For additional information: http://www.karger.com/res


Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Received: 7/9/2004
Accepted: 10/25/2004
Published online: 9/16/2005

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 2

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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