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Vol. 20, No. 5, 2005
Issue release date: October 2005
Section title: Original Paper
Cerebrovasc Dis 2005;20:299–303
(DOI:10.1159/000087928)

Interleukin 1 Beta Polymorphism (–511) and Risk of Stroke due to Small Vessel Disease

Dziedzic T. · Slowik A. · Pera J. · Szczudlik A.
Department of Neurology, Collegium Medicum, Jagiellonian University, Krakow, Poland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/11/2005
Accepted: 6/9/2005
Published online: 11/1/2005

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: Interleukin 1 (IL-1) is a proinflammatory cytokine involved in atherogenesis and thrombosis. The aim of this study was to investigate the association between the IL-1β gene polymorphism (–511) and the risk of large vessel disease (LVD) stroke, small vessel disease (SVD) stroke and cardioembolic (CE) stroke. Methods: We genotyped 115 patients with LVD stroke and 194 matched controls, 122 patients with SVD stroke and 227 controls and 221 patients with CE stroke and 219 controls. The IL-1β polymorphism was analyzed by a polymerase chain reaction followed by a restriction enzyme digestion. Results: The allele T distribution did not change significantly between patients with LVD stroke and their controls nor between patients with CE stroke and their controls. The frequency of the T allele was higher in patients with SVD stroke than in the control group (37.7 vs. 30.4%, p = 0.05). After adjustment for vascular risk factor, the TT genotype was an independent risk factor for SVD stroke (OR: 2.40, 95% CI: 1.17–4.94). Conclusions: The TT genotype of the IL-1β gene may be associated with an increased risk of SVD stroke.


  

Author Contacts

Tomasz Dziedzic, MD
Department of Neurology, Collegium Medicum, Jagiellonian University
ul. Botaniczna 3
PL–31–503 Kraków (Poland)
Tel. +48 12 424 86 00, Fax +48 12 424 86 26, E-Mail Dziedzic@cm-uj.krakow.pl

  

Article Information

Received: April 11, 2005
Accepted: June 9, 2005
Published online: August 30, 2005
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 4, Number of References : 26

  

Publication Details

Cerebrovascular Diseases

Vol. 20, No. 5, Year 2005 (Cover Date: Released October 2005)

Journal Editor: Bogousslavsky, J. (Lausanne)
ISSN: 1015–9770 (print), 1421–9786 (Online)

For additional information: http://www.karger.com/ced


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/11/2005
Accepted: 6/9/2005
Published online: 11/1/2005

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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