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Table of Contents
Vol. 60, No. 2, 2005
Issue release date: October 2005
Section title: Original Paper
Hum Hered 2005;60:63–72
(DOI:10.1159/000087971)

The Impact of Pedigree Structure on Heritability Estimates for Pulse Pressure in Three Studies

Hsu F.-C.a · Zaccaro D.J.a · Lange L.A.e · Arnett D.K.f · Langefeld C.D.a · Wagenknecht L.E.a · Herrington D.M.b · Beck S.R.a · Freedman B.I.b · Bowden D.W.b, c, d · Rich S.S.a
Departments of aPublic Health Sciences, bInternal Medicine and cBiochemistry, and dCenter for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, N.C., eDepartment of Genetics, School of Medicine, University of North Carolina, Chapel Hill, N.C., fDivision of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minn., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 23, 2004
Accepted: July 13, 2005
Published online: November 02, 2005
Issue release date: October 2005

Number of Print Pages: 10
Number of Figures: 1
Number of Tables: 4

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE

Abstract

Objectives: Pulse pressure (PP) is a measure of large artery stiffness and has been shown to be an important predictor of cardiovascular morbidity and mortality. The aims of the present study were to investigate the heritability of PP in three studies, the Diabetes Heart Study (DHS), the Insulin Resistance Atherosclerosis Family Study (IRAS FS), and the NHLBI Family Heart Study (FHS), to estimate the residual heritability after inclusion of a common set of covariates, and to investigate the impact of pedigree structure on estimating heritability. Methods and Results: DHS is primarily a sibling pair nuclear family study design, while both IRAS FS and FHS have large pedigrees. Heritability estimates of log-transformed PP were obtained using variance component models. After adjusting for age, gender, ethnicity/center, height, diabetes status, and mean arterial pressure (MAP), heritability estimates of PP were 0.40 ± 0.08 , 0.22 ± 0.05, and 0.19 ± 0.03 in DHS, IRAS FS, and FHS, respectively. The heritability estimate from DHS was significantly different from both IRAS FS and FHS (both p values <0.05). A random re-sampling technique (modified bootstrap) was used to explore the heritability in the IRAS FS and FHS data when these pedigrees were trimmed to mimic the DHS pedigree structure. The re-sampling method (mimicking a sibling pair nuclear family design in all studies) yielded PP heritability estimates of 0.37, 0.34, and 0.27 in DHS, IRAS FS, and FHS, respectively. There was no significant difference among the heritability estimates from the three studies based on the re-sampling method. Conclusion: We have shown that PP has a moderately heritable component in three different studies. These data illustrate the influence of pedigree structure can have on estimating heritability. Thoughtful comparisons of heritability estimates must consider study design factors such as pedigree structure.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 23, 2004
Accepted: July 13, 2005
Published online: November 02, 2005
Issue release date: October 2005

Number of Print Pages: 10
Number of Figures: 1
Number of Tables: 4

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: http://www.karger.com/HHE


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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