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Table of Contents
Vol. 89, No. 2, 2006
Issue release date: February 2006
Section title: Original Paper
Biol Neonate 2006;89:75–81
(DOI:10.1159/000088288)

Quantitative Measurement of Monocyte HLA-DR Expression in the Identification of Early-Onset Neonatal Infection

Ng P.C.a · Li G.a · Chui K.M.a · Chu W.C.W.b · Li K.a · Wong R.P.O.a · Fok T.F.a
Departments of aPaediatrics and bRadiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 14, 2005
Accepted: April 07, 2005
Published online: February 16, 2006
Issue release date: February 2006

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Background: This study aimed to evaluate the diagnostic utilities of monocyte HLA-DR as an infection marker in the identification of early-onset clinical infection and pneumonia in newborn infants. Methods: Term newborns in whom infection was suspected when they were <72 h of age were eligible for enrollment in the study. C-reactive protein (CRP), monocyte HLA-DR and neutrophil CD64 expressions were quantitatively measured at the time of sepsis evaluation (0 h) and 24 h afterwards by flow cytometry and standard laboratory method. Results: A total of 288 infants with suspected sepsis were investigated, and 93 were found to be clinically infected. There were no significant differences in monocyte HLA-DR expression between the infected, non-infected and control groups at 0 h (median (interquartile range): 13,986 (10,994–18,544), 14,234 (12,045–17,474) and 18,441 (14,250–21,537) antibody phycoerythrin (PE) molecules bound/cell), and between infected and non-infected infants at 24 h (median (interquartile range): 17,772 (12,933–25,167) and 19,406 (14,885–24,225) antibody PE molecules bound/cell). The areas under the receiver operating characteristics (ROC) curves for HLA-DR, CD64 and CRP were 0.52–0.54, 0.88–0.94 and 0.75–0.77, respectively. We were unable to determine an optimal cutoff value for HLA-DR, as the diagnostic utilities of any cutoff point on the ROC curves were unable to satisfy the criteria (i.e. sensitivity and specificity ≧80%) for consideration as an useful diagnostic marker of infection. Conclusions: Our findings did not support the use of monocyte HLA-DR alone or in combination with other infection markers in the diagnosis of early-onset clinical infection and pneumonia in term newborns.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 14, 2005
Accepted: April 07, 2005
Published online: February 16, 2006
Issue release date: February 2006

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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