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Table of Contents
Vol. 69, Suppl. 3, 2005
Issue release date: November 2005
Section title: Paper
Oncology 2005;69:25–33
(DOI:10.1159/000088481)

Managing Patients Treated with Bevacizumab Combination Therapy

Gordon M.S. · Cunningham D.
aArizona Cancer Center, Greater Phoenix Area, Scottsdale, Ariz., USA; bDepartment of Medicine, Royal Marsden Hospital, Surrey, UK

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/23/2005

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 7

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

The anti-angiogenic agent bevacizumab (Avastin®) has been rationally designed to target vascular endothelial growth factor (VEGF), a key mediator of tumor angiogenesis. Based on its limited roles in adults, VEGF inhibition using bevacizumab would be expected to have limited side effects. Furthermore, because its mechanism of action is different to that of standard chemotherapeutic agents, bevacizumab would not be expected to cause typical cytotoxic agent-related toxicity or to exacerbate the toxicity of concomitant chemotherapy. We have reviewed clinical trials published to date, primarily in metastatic colorectal cancer, and describe the safety profile of bevacizumab. The review focuses on hypertension, proteinuria, arterial thrombosis, effects on wound healing, bleeding and gastrointestinal (GI) perforation, which are the principal bevacizumab-related events seen in clinical trials. These events are for the most part mild to moderate in severity and clinically manageable (hypertension, proteinuria, minor bleeding) or occur uncommonly (wound healing complications, GI perforations and arterial thrombosis). The side-effect profile of bevacizumab makes it a suitable adjunct to standard chemotherapy in settings where efficacy has been demonstrated, and it is now approved for use in the USA, the European Union and other markets worldwide.


  

Author Contacts

Michael S. Gordon, MD
Arizona Cancer Center, Greater Phoenix Area
10460 N. 92nd Street, Suite 200
Scottsdale, AZ 85258 (USA)
Tel. +1 480 323 1350, Fax +1 480 323 1359, E-Mail msgordon@u.arizona.edu

  

Article Information

Published online: November 21, 2005
Number of Print Pages : 9
Number of Figures : 0, Number of Tables : 7, Number of References : 37

  

Publication Details

Oncology (International Journal of Cancer Research and Treatment)

Vol. 69, No. Suppl. 3, Year 2005 (Cover Date: Released November 2005)

Journal Editor: Trump, D.L. (Buffalo, N.Y.)
ISSN: 0030–2414 (print), 1423–0232 (Online)

For additional information: http://www.karger.com/OCL


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 11/23/2005

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 7

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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