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Original Article · Originalarbeit

Gemcitabine in the Treatment of Relapsed and Refractory Hodgkin’s Disease

Aurer I. · Radman I. · Nemet D. · Zupancic-Salek S. · Bogdanic V. · Mrsic M. · Sertic D. · Labar B.

Author affiliations

Division of Hematology, Department of Internal Medicine, University Hospital Center Rebro and Medical School, Zagreb, Croatia

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Onkologie 2005;28:567-571

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Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: October 28, 2005
Issue release date: October 2005

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 2296-5270 (Print)
eISSN: 2296-5262 (Online)

For additional information: http://www.karger.com/ORT

Abstract

Background: Patients with refractory Hodgkin’s disease or relapsing after high-dose therapy and autografting have a poor prognosis. Here, we present our experiences with gemcitabine in this setting. Patients and Methods: We treated 14 patients with relapsed or refractory Hodgkin’s disease with gemcitabine. The treatment was given on a compassionate use basis, off-label and not according to a study protocol. Patients were 17-46 years of age. 1 patient had stage IA disease, 2 patients had stage IIIB disease and 11 patients had stage IVB disease. 9 patients had received radiotherapy. 8 patients had been autografted and 1 patient auto- and allografted. Gemcitabine was administered at a starting dose of 1 g/m2 on days 1 and 8 every 3 weeks in combination with steroids. Results: The median follow-up period was 10 months. Hematological toxicity grade 3-4 occurred in 12 patients leading to dose reductions. 1 patient died of neutropenic sepsis. No other non-hematological toxicities were observed. The response rate was 64% with 6 patients achieving complete remission (CR) and 3 patients partial remission (PR). The median time to treatment failure was 9 months, and survival was 11 months. Responses were seen in previously transplanted patients and in patients refractory to previous treatment. The so far longest responder has been in CR for over 68 months. Conclusion: Gemcitabine is an effective treatment for Hodgkin’s disease. Heavily pretreated patients often require dose reductions.


Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: October 28, 2005
Issue release date: October 2005

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 2296-5270 (Print)
eISSN: 2296-5262 (Online)

For additional information: http://www.karger.com/ORT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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