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Cover

Parasites and Allergy

Editor(s): Capron M. (Lille) 
Trottein F. (Lille) 
Table of Contents
Vol. 90, No. , 2006
Section title: Paper
Capron M, Trottein F (eds): Parasites and Allergy. Chem Immunol Allergy. Basel, Karger, 2006, vol 90, pp 82-90
(DOI:10.1159/000088882)

Regulation of Dendritic Cell Function by Pathogen-Derived Molecules Plays a Key Role in Dictating the Outcome of the Adaptive Immune Response

Pearce E.J. · Kane C. · Sun J.
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pa., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: October 06, 2005
Cover Date: 2006

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-7974-2 (Print)
eISBN: 978-3-318-01251-4 (Online)

Abstract

There is increasing awareness that dendritic cells (DCs) can interpret pathogen-inherent signals and play a pivotal role in polarizing Th cell differentiation. Polarized Th1 responses are induced by DCs, which respond to pathogen-derived TLR ligands to mature and produce IL-12 and related cytokines that are instrumental in Th1 cell outgrowth. In contrast, DCs exposed to SEA (soluble egg Ag from the helminth parasite Schistosoma mansoni) retain a (modified) immature phenotype and induce Th2 responses. In addition to providing positive signals for Th1 cell development, DCs activated to mature by TLR-engagement also provide a potent negative signal that prevents the development of Th2 cells. Production of this signal is dependent upon a MyD88-dependent signaling pathway in DCs. In contrast, exposure of DCs to SEA severely limits their ability to respond to inflammatory TLR ligands such as LPS and CpG. Thus as part of their pathogen-specific response programs, DC can exert negative as well as positive signals for Th response polarization. These effects may have powerful and systemic effects on disease outcome.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: October 06, 2005
Cover Date: 2006

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-7974-2 (Print)
eISBN: 978-3-318-01251-4 (Online)


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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