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Vol. 212, No. 1, 2006
Issue release date: November 2005
Section title: Clinical and Laboratory Investigations
Dermatology 2006;212:53–58
(DOI:10.1159/000089023)

Two Distinct Types of Speckled Lentiginous Nevi Characterized by Macular versus Papular Speckles

Vidaurri-de la Cruz H. · Happle R.
Department of Dermatology, Philipp University of Marburg, Marburg, Germany

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Received: 1/6/2005
Accepted: 6/2/2005
Published online: 1/20/2006

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 4

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: Speckled lentiginous nevus (SLN; synonym: nevus spilus) is a darkly spotted light-brown macule that mostly occurs as an isolated lesion of rather limited dimensions but sometimes may involve large areas of the body. So far, this skin disorder has been considered to represent one clinical entity. Objective: Because SLN is occasionally associated with complex birth defects such as phacomatosis pigmentovascularis, phacomatosis pigmentokeratotica, or SLN syndrome, we tested our idea that two different types of SLN may exist, each one associated with a particular syndrome. Methods: A review of case reports on SLN published during the years 1970–2004 was performed. Results: This evaluation of cases provided evidence that two different types of SLN exist, in the form of macular versus papular SLN, each one being related to a specific syndrome. Macular SLN is characterized by a tannish-brown background with darker flat speckles. The distribution of speckles is rather even and resembles a polka-dot pattern. Histopathologically, this type of SLN is characterized by what has been called a ‘jentigo’ pattern in the darker speckles and by some nests of melanocytes at the dermoepidermal junction at the tips of the papillae, whereas the background pigmentation shows the microscopical features of a lentigo. Papular SLN is characterized by a light-brown macule superimposed by multiple melanocytic nevi in the form of papules or nodules that show a more uneven distribution reminiscent of a star map. Small dark macules may likewise be present. Histopathologically, the papular component consists of dermal or compound melanocytic nevi. A separation of the two types of SLN is important because our analysis showed that macular SLN is a hallmark of a particular type of phacomatosis pigmentovascularis, whereas papular SLN is typically present in phacomatosis pigmentokeratotica as well as in SLN syndrome. Conclusions: Macular SLN and papular SLN appear to be two distinct cutaneous entities. This dichotomy may turn out to be important when such nevi will be analyzed at the molecular level.


  

Author Contacts

Rudolf Happle
Department of Dermatology, University of Marburg
Deutschhaus-Strasse 9
DE–35033 Marburg (Germany)
Tel. +49 6421 2862908, Fax +49 6421 2862898, E-Mail happle@med.uni-marburg.de

  

Article Information

Received: January 6, 2005
Accepted: May 27, 2005
Number of Print Pages : 6
Number of Figures : 4, Number of Tables : 4, Number of References : 75

  

Publication Details

Dermatology

Vol. 212, No. 1, Year 2006 (Cover Date: November 2005)

Journal Editor: Saurat, J.-H. (Geneva)
ISSN: 1018–8665 (print), 1421–9832 (Online)

For additional information: http://www.karger.com/DRM


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigations

Received: 1/6/2005
Accepted: 6/2/2005
Published online: 1/20/2006

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 4

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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