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Vol. 21, No. 1, 2006
Issue release date: December 2005
Section title: Paper
Fetal Diagn Ther 2006;21:84–91
(DOI:10.1159/000089055)

Increased Expression of Vascular Endothelial Growth Factor in Cardiac Structures of Fetus with Hydrops as Compared to Nonhydropic Controls

Brandenburg H. · Bartelings M.M. · Wisse L.J. · Steegers E.A.P. · Gittenberger-de Groot A.C.
aDepartment of Obstetrics and Gynecology, Erasmus Medical Center, University of Rotterdam, Rotterdam, and bDepartment of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 7/13/2004
Accepted: 12/21/2004
Published online: 12/15/2005

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 4

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT

Abstract

Objective: The hypothesis that severe fetal hydrops is caused by an excess of vascular endothelial growth factor (VEGF), mainly produced in the fetal heart, is tested. Methods: Immunohistochemical VEGF-stained postmortem biopsies from the right ventricle and right atrium of 8 hydropic fetuses were compared to those of 8 nonhydropic fetuses. The endocardium, myocardium, epicardium, endothelium, and vascular smooth muscle cells were scored on intensity of VEGF-staining. The Mann-Witney test was used to test for significancy (p < 0.05) of the differences in staining. Increased vascularization as a result of VEGF was measured in both groups by standard randomization count. Results: The endocardium, epicardium and endothelium of the coronary vessels showed significantly (p < 0.05) more intense VEGF-staining in the hydrops group than in the control group. The atria showed more intense staining than the ventricles in both groups. The hydropic fetuses showed a significantly increased number of coronary vessels in the myocardium. These vessels contained more blood cells than the coronary vessels in nonhydropic fetuses. Conclusion: The fetal heart appears to be a major source of excess VEGF in fetal hydrops.


  

Author Contacts

Dr. H. Brandenburg, Gynecologist
Department of Obstetrics and Gynecology
Dr. Molewaterplein 40
NL–3015 GD Rotterdam (The Netherlands)
Tel. +31 10 4633917, Fax +31 10 4635826, E-Mail h.brandenburg.1@erasmusmc.nl

  

Article Information

Received: July 13, 2004
Accepted after revision: December 21, 2004
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 4, Number of References : 40

  

Publication Details

Fetal Diagnosis and Therapy (Clinical Advances and Basic Research)

Vol. 21, No. 1, Year 2006 (Cover Date: December 2005)

Journal Editor: Holzgreve, W. (Basel)
ISSN: 1015–3837 (print), 1421–9964 (Online)

For additional information: http://www.karger.com/FDT


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: 7/13/2004
Accepted: 12/21/2004
Published online: 12/15/2005

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 4

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT


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