Olanzapine versus Haloperidol in the Treatment of Agitation in Elderly Patients with Dementia: Results of a Randomized Controlled Double-Blind TrialVerhey F.R.J.a · Verkaaik M.b · Lousberg R.a
aDepartment of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, and bPrins Claus Center for Mental Health, Sittard, The Netherlands
The goal of this study was to compare the efficacy and safety of olanzapine versus haloperidol in the treatment of agitation and aggression in patients with dementia. The subjects were 58 out-patients with dementia and agitation. After baseline assessments and, if necessary, a period of wash-out of a previous antipsychotic drug, they were randomly assigned to 5 weeks of double-blind treatment with either olanzapine or haloperidol. The first 2 weeks were used for dose titration. Subsequently, the patients received a fixed dose of either olanzapine (average dose 4.71 mg) or haloperidol (average dose 1.75 mg) from day 14 to day 35. Both olanzapine and haloperidol decreased agitation significantly (decrease in Cohen-Mansfield Agitation Inventory scores), but there was no significant difference between the two drugs. The two drugs had comparable effects on all secondary outcome measures. They were well tolerated and had a similar side-effect pattern. Our study could not demonstrate the superiority of olanzapine, compared to haloperidol, for the treatment of agitation in patients with dementia.
© 2006 S. Karger AG, Basel
The olanzapine study group consisted of: Mike Verkaaik, project coordinator, Prins Claus Centrum Sittard; Frans Verhey, project leader, and Richel Lousberg, University Hospital of Maastricht, the Netherlands; Judith Tummers, Prins Claus Centrum Sittard, now working in Mondriaan Zorggroep, Heerlen; Marina van Montfort, Prins Claus Centrum, Sittard; Victor Chel, Mariënhave, Warmond; Lilly Nass, de Hogewei, Weesp; Marc Peeters, GGZ Den Bosch, now working in GGZ Land van Cuijck, Boxmeer; Marianne van den Boogerd, PMS Vijverdal, Maastricht.
Accepted: July 24, 2005
Published online: October 21, 2005
Number of Print Pages : 8
Number of Figures : 0, Number of Tables : 3, Number of References : 30
Dementia and Geriatric Cognitive Disorders
Vol. 21, No. 1, Year 2006 (Cover Date: December 2005)
Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/dem