Relationship between Delusions and Regional Cerebral Blood Flow in Alzheimer’s DiseaseNakano S. · Yamashita F. · Matsuda H. · Kodama C. · Yamada T.
aDepartment of Internal Medicine, Fukuoka University, Fukuoka, bNational Center of Neurology and Psychiatry (NCNP), Musashi Hospital,Tokyo, and cDepartment of Nuclear Medicine, Saitama Medical School Hospital, Saitama, Japan
To investigate the association between delusions and cerebral functional deficits in Alzheimer’s disease (AD), we evaluated probable AD patients with and without delusions. Methods: Functional brain imaging was performed by single photon emission computed tomography with technetium-99m-labeled ethyl cysteinate dimer (99mTc-ECD) in 64 AD patients and 76 age-matched normal healthy volunteers. SPECT data were analyzed by statistical parametric mapping. Results: In AD patients, no differences were found in age and cognitive activities between those with (n = 25) and without (n = 39) delusions. Compared with normal healthy volunteers, AD patients had significantly decreased perfusion in the posterior cingulate gyri, precunei, and parietal association cortex. Moreover, in the patients with delusions, perfusion was significantly decreased in the frontal lobe with right side dominance. In the comparison between the patients with and without delusions, the patients with delusions had significantly decreased perfusion in the prefrontal cortex, anterior cingulate gyri, inferior to middle temporal cortices, and parietal cortex of the right hemisphere (p < 0.01). Conclusion: The functional deficits in the right hemisphere may be the cause of delusions in AD.
Seigo Nakano, MD
5th Department of Internal Medicine
Fukuoka 814-9180 (Japan)
Tel. +81 92 801 1011, ext. 3525, Fax +81 92 865 7900, E-Mail firstname.lastname@example.org
Accepted: July 18, 2005
Published online: October 25, 2005
Number of Print Pages : 6
Number of Figures : 4, Number of Tables : 1, Number of References : 30
Dementia and Geriatric Cognitive Disorders
Vol. 21, No. 1, Year 2006 (Cover Date: December 2005)
Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/dem