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Vol. 37, No. 5, 2005
Issue release date: September–October 2005
Section title: Original Paper
Eur Surg Res 2005;37:274–280
(DOI:10.1159/000089234)

Neutrophil Elastase Inhibitor Ameliorates Reperfusion Injury in a Canine Model of Lung Transplantation

Aoki T. · Tsuchida M. · Takekubo M. · Saito M. · Sato K. · Hayashi J.
Department of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/16/2005
Accepted: 9/6/2005
Published online: 12/23/2005

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 2

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: http://www.karger.com/ESR

Abstract

Background: We investigated the effects of neutrophil elastase inhibitor ONO-5046 Na on lung ischemia-reperfusion injury in a canine model of single lung transplantation. Methods: 24 mongrel dogs, 12 donors and 12 recipients, were used for single lung transplantation. Lung grafts were preserved for 18 h by cold ischemia then transplanted into the left thoracic cavity of recipients. In 6 recipients (ONO group), a bolus of ONO-5046 Na (10 mg/kg) was introduced before reperfusion and followed by continuous infusion (10 mg/kg/h). The remaining 6 recipients (control group) did not receive ONO-5046 Na and thus served as controls. We evaluated lung function and respiratory parameters over 240 min. Results: The total cell number in bronchoalveolar lavage fluid increased significantly in the control group in comparison to that in the ONO group. Histologic scores after 4 h of reperfusion and myeloperoxidase activity were significantly lower in the ONO group than in the control group. Conclusion: Neutrophil elastase inhibitor ONO-5046 Na may be useful in ameliorating lung reperfusion injury after transplantation.


  

Author Contacts

Tadashi Aoki, MD
Department of Thoracic and Cardiovascular Surgery
Niigata University Graduate School of Medical and Dental Sciences
1-757 Asahimachi, Niigata City 951-8510 (Japan)
Tel. +81 25 227 2243, Fax +81 25 227 0780, E-Mail taoki@med.niigata-u.ac.jp

  

Article Information

Received: February 16, 2005
Accepted after revision: September 6, 2005
Number of Print Pages : 7
Number of Figures : 4, Number of Tables : 2, Number of References : 21

  

Publication Details

European Surgical Research (Clinical and Experimental Surgery)

Vol. 37, No. 5, Year 2005 (Cover Date: September-October 2005)

Journal Editor: Messmer, K. (Munich)
ISSN: 0014–312X (print), 1421–9921 (Online)

For additional information: http://www.karger.com/ESR


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/16/2005
Accepted: 9/6/2005
Published online: 12/23/2005

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 2

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: http://www.karger.com/ESR


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