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Vol. 64, Suppl. 3, 2005
Issue release date: February 2006
Section title: Insulin Sensitivity: Clinical Impact
Horm Res 2005;64:58–65
(DOI:10.1159/000089319)

Babies Born Small for Gestational Age: Insulin Sensitivity and Growth Hormone Treatment

Dunger D.B. · Ong K.K.
University of Cambridge, Department of Paediatrics, Addenbrooke’s Hospital, Cambridge, UK

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Article / Publication Details

First-Page Preview
Abstract of Insulin Sensitivity: Clinical Impact

Published online: 1/27/2006
Issue release date: February 2006

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Epidemiological studies have identified an association between size at birth and adult risk for type 2 diabetes mellitus and cardiovascular disease. In contemporary populations, children who are relatively small at birth and show rapid infancy weight gain are at greatest risk for the development of childhood obesity, increased visceral fat and insulin resistance: possible early markers of adult disease risk. Individuals presenting to growth clinics with short stature and a history of low birthweight will not have shown post-natal catch-up growth and may be a very heterogeneous group. Nevertheless, there are some data to suggest that as a group they are insulin resistant with decreased lean mass. Growth hormone treatment leads to reversible worsening of the insulin resistance, and short-term data do not indicate an increased risk for type 2 diabetes. However, further long-term follow-up is required, and particular care should be taken in monitoring children with a strong family history of type 2 diabetes and those from ethnic groups in which there is a high background prevalence of the disease.

© 2005 S. Karger AG, Basel


  

Author Contacts

Prof. D.B. Dunger
Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital
Box 116, Level 8, Hills Road
Cambridge, CB2 2QQ (UK)
Tel. +44 1223 762944, Fax +44 1223 336996, E-Mail dbd25@cam.ac.uk

  

Article Information

Published online: January 20, 2006
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 1, Number of References : 71

  

Publication Details

Hormone Research (From Developmental Endocrinology to Clinical Research)

Vol. 64, No. Suppl. 3, Year 2005 (Cover Date: February 2006)

Journal Editor: Czernichow, P. (Paris)
ISSN: 0301–0163 (print), 1423–0046 (Online)

For additional information: http://www.karger.com/HRE


Article / Publication Details

First-Page Preview
Abstract of Insulin Sensitivity: Clinical Impact

Published online: 1/27/2006
Issue release date: February 2006

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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